E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK–CBL–CIN85 axis

Casitas B-lineage lymphoma (CBL) is a ubiquitin ligase (E3) that becomes activated upon Tyr371-phosphorylation and targets receptor protein tyrosine kinases for ubiquitin-mediated degradation. Deregulation of CBL and its E3 activity is observed in myeloproliferative neoplasms and other cancers, incl...

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Detalles Bibliográficos
Autores principales: Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads, Lilla, Sergio, Sibbet, Gary J., Sumpton, David, Zanivan, Sara, Hedley, Ann, Clark, William, Huang, Danny T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994203/
https://www.ncbi.nlm.nih.gov/pubmed/33627783
http://dx.doi.org/10.1038/s41388-021-01684-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994203/
https://www.ncbi.nlm.nih.gov/pubmed/33627783
http://dx.doi.org/10.1038/s41388-021-01684-x

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