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Beneficial effect of retigabine on memory in rats receiving ethanol
BACKGROUND: Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994244/ https://www.ncbi.nlm.nih.gov/pubmed/33385172 http://dx.doi.org/10.1007/s43440-020-00205-z |
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author | Zwierzyńska, Ewa Krupa-Burtnik, Agata Pietrzak, Bogusława |
author_facet | Zwierzyńska, Ewa Krupa-Burtnik, Agata Pietrzak, Bogusława |
author_sort | Zwierzyńska, Ewa |
collection | PubMed |
description | BACKGROUND: Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memory and learning such as the hippocampus. In our previous study, retigabine reduced hippocampal changes induced by ethanol in the EEG rhythms in rabbits. This study is focused on the impact of retigabine on memory processes in male rats receiving alcohol. METHODS: Memory was evaluated in various experimental models: Morris water maze, Contextual, and Cued Fear Conditioning tests. Retigabine was administered for 3 weeks directly to the stomach via oral gavage at a dose of 10 mg/kg. Rats received also 20% ethanol (5 g/kg/day in two doses) via oral gavage for 3 weeks and had free access to 5% ethanol in the afternoon and at night. Morris water maze was performed after 1 and 3 weeks of ethanol administration and after 1 week from the discontinuation of ethanol administration. Contextual and Cued Fear Conditioning tests were carried out after 24 h and 72 h of alcohol discontinuation. RESULTS: The drug significantly decreased ethanol-induced memory disturbances during alcohol administration as well as slightly improved learning processes after the discontinuation of ethanol administration. CONCLUSIONS: This beneficial effect of retigabine-ethanol interaction on memory may be a relevant element of the drug’s impact on the development of addiction. |
format | Online Article Text |
id | pubmed-7994244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-79942442021-04-16 Beneficial effect of retigabine on memory in rats receiving ethanol Zwierzyńska, Ewa Krupa-Burtnik, Agata Pietrzak, Bogusława Pharmacol Rep Article BACKGROUND: Retigabine belongs to the novel generation of antiepileptic drugs but its complex mechanism of action causes that the drug might be effective in other diseases, for instance, alcohol dependence. It is known that ethanol abuse impaired the function of brain structures associated with memory and learning such as the hippocampus. In our previous study, retigabine reduced hippocampal changes induced by ethanol in the EEG rhythms in rabbits. This study is focused on the impact of retigabine on memory processes in male rats receiving alcohol. METHODS: Memory was evaluated in various experimental models: Morris water maze, Contextual, and Cued Fear Conditioning tests. Retigabine was administered for 3 weeks directly to the stomach via oral gavage at a dose of 10 mg/kg. Rats received also 20% ethanol (5 g/kg/day in two doses) via oral gavage for 3 weeks and had free access to 5% ethanol in the afternoon and at night. Morris water maze was performed after 1 and 3 weeks of ethanol administration and after 1 week from the discontinuation of ethanol administration. Contextual and Cued Fear Conditioning tests were carried out after 24 h and 72 h of alcohol discontinuation. RESULTS: The drug significantly decreased ethanol-induced memory disturbances during alcohol administration as well as slightly improved learning processes after the discontinuation of ethanol administration. CONCLUSIONS: This beneficial effect of retigabine-ethanol interaction on memory may be a relevant element of the drug’s impact on the development of addiction. Springer International Publishing 2020-12-31 2021 /pmc/articles/PMC7994244/ /pubmed/33385172 http://dx.doi.org/10.1007/s43440-020-00205-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zwierzyńska, Ewa Krupa-Burtnik, Agata Pietrzak, Bogusława Beneficial effect of retigabine on memory in rats receiving ethanol |
title | Beneficial effect of retigabine on memory in rats receiving ethanol |
title_full | Beneficial effect of retigabine on memory in rats receiving ethanol |
title_fullStr | Beneficial effect of retigabine on memory in rats receiving ethanol |
title_full_unstemmed | Beneficial effect of retigabine on memory in rats receiving ethanol |
title_short | Beneficial effect of retigabine on memory in rats receiving ethanol |
title_sort | beneficial effect of retigabine on memory in rats receiving ethanol |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994244/ https://www.ncbi.nlm.nih.gov/pubmed/33385172 http://dx.doi.org/10.1007/s43440-020-00205-z |
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