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Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection

In this paper, we report the effect of optical trapping on the enhancement factor for Raman spectroscopy, using a dielectric metasurface. It was found that a higher enhancement factor (up to 275%) can be obtained in a substrate immersed in water, where particles are freee to move, compared to a drie...

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Autores principales: Kenworthy, Cameron F., Pjotr Stoevelaar, L., Alexander, Andrew J., Gerini, Giampiero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994300/
https://www.ncbi.nlm.nih.gov/pubmed/33767266
http://dx.doi.org/10.1038/s41598-021-85965-1
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author Kenworthy, Cameron F.
Pjotr Stoevelaar, L.
Alexander, Andrew J.
Gerini, Giampiero
author_facet Kenworthy, Cameron F.
Pjotr Stoevelaar, L.
Alexander, Andrew J.
Gerini, Giampiero
author_sort Kenworthy, Cameron F.
collection PubMed
description In this paper, we report the effect of optical trapping on the enhancement factor for Raman spectroscopy, using a dielectric metasurface. It was found that a higher enhancement factor (up to 275%) can be obtained in a substrate immersed in water, where particles are freee to move, compared to a dried substrate, where the particles (radius [Formula: see text]  nm, refractive index [Formula: see text] ) are fixed on the surface. The highest enhancement is obtained at low concentrations because, this case, the particles are trapped preferentially in the regions of highest electric field (hotspots). For high concentrations, it was observed that the hotspots become saturated with particles and that additional particles are forced to occupy regions of lower field. The dielectric metasurface offers low optical absorption compared to conventional gold substrates. This aspect can be important for temperature-sensitive applications. The method shows potential for applications in crystal nucleation, where high solute supersaturation can be achieved near the high-field regions of the metasurface. The high sensitivity for SERS (surface-enhanced Raman spectroscopy) at low analyte concentrations makes the proposed method highly promising for detection of small biological particles, such as proteins or viruses.
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spelling pubmed-79943002021-03-26 Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection Kenworthy, Cameron F. Pjotr Stoevelaar, L. Alexander, Andrew J. Gerini, Giampiero Sci Rep Article In this paper, we report the effect of optical trapping on the enhancement factor for Raman spectroscopy, using a dielectric metasurface. It was found that a higher enhancement factor (up to 275%) can be obtained in a substrate immersed in water, where particles are freee to move, compared to a dried substrate, where the particles (radius [Formula: see text]  nm, refractive index [Formula: see text] ) are fixed on the surface. The highest enhancement is obtained at low concentrations because, this case, the particles are trapped preferentially in the regions of highest electric field (hotspots). For high concentrations, it was observed that the hotspots become saturated with particles and that additional particles are forced to occupy regions of lower field. The dielectric metasurface offers low optical absorption compared to conventional gold substrates. This aspect can be important for temperature-sensitive applications. The method shows potential for applications in crystal nucleation, where high solute supersaturation can be achieved near the high-field regions of the metasurface. The high sensitivity for SERS (surface-enhanced Raman spectroscopy) at low analyte concentrations makes the proposed method highly promising for detection of small biological particles, such as proteins or viruses. Nature Publishing Group UK 2021-03-25 /pmc/articles/PMC7994300/ /pubmed/33767266 http://dx.doi.org/10.1038/s41598-021-85965-1 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kenworthy, Cameron F.
Pjotr Stoevelaar, L.
Alexander, Andrew J.
Gerini, Giampiero
Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection
title Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection
title_full Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection
title_fullStr Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection
title_full_unstemmed Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection
title_short Using the near field optical trapping effect of a dielectric metasurface to improve SERS enhancement for virus detection
title_sort using the near field optical trapping effect of a dielectric metasurface to improve sers enhancement for virus detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994300/
https://www.ncbi.nlm.nih.gov/pubmed/33767266
http://dx.doi.org/10.1038/s41598-021-85965-1
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