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Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate MC4R function. Most obesity-associated mutations impair trafficking to the plasma membrane (PM), w...
Autores principales: | Brouwers, Bas, de Oliveira, Edson Mendes, Marti-Solano, Maria, Monteiro, Fabiola B.F., Laurin, Suli-Anne, Keogh, Julia M., Henning, Elana, Bounds, Rebecca, Daly, Carole A., Houston, Shane, Ayinampudi, Vikram, Wasiluk, Natalia, Clarke, David, Plouffe, Bianca, Bouvier, Michel, Babu, M. Madan, Farooqi, I. Sadaf, Mokrosiński, Jacek |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994375/ https://www.ncbi.nlm.nih.gov/pubmed/33761344 http://dx.doi.org/10.1016/j.celrep.2021.108862 |
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