Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis

Candida infections of the central nervous system (CNS) are rare. We report a case of Candida glabrata meningitis successfully treated with combination antifungal therapy followed by step-down therapy with fluconazole. New-onset hypercalcaemia, an uncommon side effect of the prolonged fluconazole tre...

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Detalles Bibliográficos
Autores principales: Wee, Liang En, Wong, Crystal Shie Lyeen, Tan, Ai Ling, Oh, Helen May-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994442/
https://www.ncbi.nlm.nih.gov/pubmed/33786294
http://dx.doi.org/10.1016/j.mmcr.2021.03.003
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author Wee, Liang En
Wong, Crystal Shie Lyeen
Tan, Ai Ling
Oh, Helen May-Lin
author_facet Wee, Liang En
Wong, Crystal Shie Lyeen
Tan, Ai Ling
Oh, Helen May-Lin
author_sort Wee, Liang En
collection PubMed
description Candida infections of the central nervous system (CNS) are rare. We report a case of Candida glabrata meningitis successfully treated with combination antifungal therapy followed by step-down therapy with fluconazole. New-onset hypercalcaemia, an uncommon side effect of the prolonged fluconazole treatment, prompted early treatment cessation. A negative cerebrospinal fluid (CSF) β-d-glucan supported the decision of treatment cessation despite incomplete resolution of CSF biochemical parameters. No disease relapse was encountered after 2 years post-treatment.
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spelling pubmed-79944422021-03-29 Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis Wee, Liang En Wong, Crystal Shie Lyeen Tan, Ai Ling Oh, Helen May-Lin Med Mycol Case Rep Case Report Candida infections of the central nervous system (CNS) are rare. We report a case of Candida glabrata meningitis successfully treated with combination antifungal therapy followed by step-down therapy with fluconazole. New-onset hypercalcaemia, an uncommon side effect of the prolonged fluconazole treatment, prompted early treatment cessation. A negative cerebrospinal fluid (CSF) β-d-glucan supported the decision of treatment cessation despite incomplete resolution of CSF biochemical parameters. No disease relapse was encountered after 2 years post-treatment. Elsevier 2021-03-05 /pmc/articles/PMC7994442/ /pubmed/33786294 http://dx.doi.org/10.1016/j.mmcr.2021.03.003 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wee, Liang En
Wong, Crystal Shie Lyeen
Tan, Ai Ling
Oh, Helen May-Lin
Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis
title Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis
title_full Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis
title_fullStr Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis
title_full_unstemmed Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis
title_short Negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: A case report of Candida glabrata meningitis
title_sort negative cerebrospinal fluid β-d-glucan levels as an indicator for treatment cessation ahead of biochemical resolution: a case report of candida glabrata meningitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994442/
https://www.ncbi.nlm.nih.gov/pubmed/33786294
http://dx.doi.org/10.1016/j.mmcr.2021.03.003
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