Ploidy dynamics increase the risk of liver cancer initiation

Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.

Detalles Bibliográficos
Autores principales: Müller, Miryam, May, Stephanie, Bird, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994546/
https://www.ncbi.nlm.nih.gov/pubmed/33767143
http://dx.doi.org/10.1038/s41467-021-21897-8
Descripción
Sumario:Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.

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