Ploidy dynamics increase the risk of liver cancer initiation

Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.

Detalles Bibliográficos
Autores principales: Müller, Miryam, May, Stephanie, Bird, Thomas G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994546/
https://www.ncbi.nlm.nih.gov/pubmed/33767143
http://dx.doi.org/10.1038/s41467-021-21897-8
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author Müller, Miryam
May, Stephanie
Bird, Thomas G.
author_facet Müller, Miryam
May, Stephanie
Bird, Thomas G.
author_sort Müller, Miryam
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description Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours.
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spelling pubmed-79945462021-04-16 Ploidy dynamics increase the risk of liver cancer initiation Müller, Miryam May, Stephanie Bird, Thomas G. Nat Commun Comment Liver cancer typically arises after years of inflammatory insults to hepatocytes. These cells can change their ploidy state during health and disease. Whilst polyploidy may offer some protection, new research shows it may also promote the formation of liver tumours. Nature Publishing Group UK 2021-03-25 /pmc/articles/PMC7994546/ /pubmed/33767143 http://dx.doi.org/10.1038/s41467-021-21897-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Müller, Miryam
May, Stephanie
Bird, Thomas G.
Ploidy dynamics increase the risk of liver cancer initiation
title Ploidy dynamics increase the risk of liver cancer initiation
title_full Ploidy dynamics increase the risk of liver cancer initiation
title_fullStr Ploidy dynamics increase the risk of liver cancer initiation
title_full_unstemmed Ploidy dynamics increase the risk of liver cancer initiation
title_short Ploidy dynamics increase the risk of liver cancer initiation
title_sort ploidy dynamics increase the risk of liver cancer initiation
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994546/
https://www.ncbi.nlm.nih.gov/pubmed/33767143
http://dx.doi.org/10.1038/s41467-021-21897-8
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