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Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling

Activating intra-tumor innate immunity might enhance tumor immune surveillance. Virotherapy is proposed to achieve tumor cell killing, while indirectly activating innate immunity. Here, we report that recombinant poliovirus therapy primarily mediates antitumor immunotherapy via direct infection of n...

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Detalles Bibliográficos
Autores principales:	Brown, Michael C., Mosaheb, Mubeen M., Mohme, Malte, McKay, Zachary P., Holl, Eda K., Kastan, Jonathan P., Yang, Yuanfan, Beasley, Georgia M., Hwang, E. Shelley, Ashley, David M., Bigner, Darell D., Nair, Smita K., Gromeier, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994570/ https://www.ncbi.nlm.nih.gov/pubmed/33767151 http://dx.doi.org/10.1038/s41467-021-22088-1

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