Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism

Accurate gene transcription in eukaryotes depends on isomerization of serine-proline bonds within the carboxy-terminal domain (CTD) of RNA polymerase II. Isomerization is part of the “CTD code” that regulates recruitment of proteins required for transcription and co-transcriptional RNA processing. S...

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Detalles Bibliográficos
Autores principales: Namitz, Kevin E. W., Zheng, Tongyin, Canning, Ashley J., Alicea-Velazquez, Nilda L., Castañeda, Carlos A., Cosgrove, Michael S., Hanes, Steven D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994582/
https://www.ncbi.nlm.nih.gov/pubmed/33767358
http://dx.doi.org/10.1038/s42003-021-01906-8

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