Cargando…

Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics

This study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Min Jye, Jang, Sung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994646/
https://www.ncbi.nlm.nih.gov/pubmed/33767378
http://dx.doi.org/10.1038/s41598-021-86439-0
_version_ 1783669796830707712
author Cho, Min Jye
Jang, Sung Ho
author_facet Cho, Min Jye
Jang, Sung Ho
author_sort Cho, Min Jye
collection PubMed
description This study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recruited to the study. Correlation coefficients were calculated to observe the relationships among the PTA duration, white matter fractional anisotropy (FA) values, and mini-mental state examination (MMSE) results in the patient group. Both before and after Benjamini–Hochberg (BH) corrections, FA values of 46 of the 48 regions of interests of the patient group were lower than those of the control group. The FA values of column and body of fornix, left crus of fornix, left uncinate fasciculus, right hippocampus part of cingulum, left medial lemniscus, right superior cerebellar peduncle, left superior cerebellar peduncle, and left posterior thalamic radiation (after BH correction: the uncinate fasciculus and right hippocampus part of cingulum) in the patient group were negatively correlated with PTA duration. PTA duration was related to the injury severity of eight neural structures, each of which is involved in the cognitive functioning of patients with TBI. Therefore, PTA duration can indicate injury severity of the above neural structures in TBI patients.
format Online
Article
Text
id pubmed-7994646
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-79946462021-03-29 Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics Cho, Min Jye Jang, Sung Ho Sci Rep Article This study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recruited to the study. Correlation coefficients were calculated to observe the relationships among the PTA duration, white matter fractional anisotropy (FA) values, and mini-mental state examination (MMSE) results in the patient group. Both before and after Benjamini–Hochberg (BH) corrections, FA values of 46 of the 48 regions of interests of the patient group were lower than those of the control group. The FA values of column and body of fornix, left crus of fornix, left uncinate fasciculus, right hippocampus part of cingulum, left medial lemniscus, right superior cerebellar peduncle, left superior cerebellar peduncle, and left posterior thalamic radiation (after BH correction: the uncinate fasciculus and right hippocampus part of cingulum) in the patient group were negatively correlated with PTA duration. PTA duration was related to the injury severity of eight neural structures, each of which is involved in the cognitive functioning of patients with TBI. Therefore, PTA duration can indicate injury severity of the above neural structures in TBI patients. Nature Publishing Group UK 2021-03-25 /pmc/articles/PMC7994646/ /pubmed/33767378 http://dx.doi.org/10.1038/s41598-021-86439-0 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cho, Min Jye
Jang, Sung Ho
Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_full Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_fullStr Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_full_unstemmed Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_short Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
title_sort relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994646/
https://www.ncbi.nlm.nih.gov/pubmed/33767378
http://dx.doi.org/10.1038/s41598-021-86439-0
work_keys_str_mv AT chominjye relationshipbetweenposttraumaticamnesiaandwhitematterintegrityintraumaticbraininjuryusingtractbasedspatialstatistics
AT jangsungho relationshipbetweenposttraumaticamnesiaandwhitematterintegrityintraumaticbraininjuryusingtractbasedspatialstatistics