The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization

Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that...

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Autores principales: Zou, Jing, Xie, Xuping, Fontes-Garfias, Camila R., Swanson, Kena A., Kanevsky, Isis, Tompkins, Kristin, Cutler, Mark, Cooper, David, Dormitzer, Philip R., Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994717/
https://www.ncbi.nlm.nih.gov/pubmed/33767200
http://dx.doi.org/10.1038/s41541-021-00313-8
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author Zou, Jing
Xie, Xuping
Fontes-Garfias, Camila R.
Swanson, Kena A.
Kanevsky, Isis
Tompkins, Kristin
Cutler, Mark
Cooper, David
Dormitzer, Philip R.
Shi, Pei-Yong
author_facet Zou, Jing
Xie, Xuping
Fontes-Garfias, Camila R.
Swanson, Kena A.
Kanevsky, Isis
Tompkins, Kristin
Cutler, Mark
Cooper, David
Dormitzer, Philip R.
Shi, Pei-Yong
author_sort Zou, Jing
collection PubMed
description Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7–2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial.
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spelling pubmed-79947172021-04-16 The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization Zou, Jing Xie, Xuping Fontes-Garfias, Camila R. Swanson, Kena A. Kanevsky, Isis Tompkins, Kristin Cutler, Mark Cooper, David Dormitzer, Philip R. Shi, Pei-Yong NPJ Vaccines Brief Communication Initial COVID-19 vaccine candidates were based on the original sequence of SARS-CoV-2. However, the virus has since accumulated mutations, among which the spike D614G is dominant in circulating virus, raising questions about potential virus escape from vaccine-elicited immunity. Here, we report that the D614G mutation modestly reduced (1.7–2.4-fold) SARS-CoV-2 neutralization by BNT162b2 vaccine-elicited mouse, rhesus, and human sera, concurring with the 95% vaccine efficacy observed in clinical trial. Nature Publishing Group UK 2021-03-25 /pmc/articles/PMC7994717/ /pubmed/33767200 http://dx.doi.org/10.1038/s41541-021-00313-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Zou, Jing
Xie, Xuping
Fontes-Garfias, Camila R.
Swanson, Kena A.
Kanevsky, Isis
Tompkins, Kristin
Cutler, Mark
Cooper, David
Dormitzer, Philip R.
Shi, Pei-Yong
The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization
title The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization
title_full The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization
title_fullStr The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization
title_full_unstemmed The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization
title_short The effect of SARS-CoV-2 D614G mutation on BNT162b2 vaccine-elicited neutralization
title_sort effect of sars-cov-2 d614g mutation on bnt162b2 vaccine-elicited neutralization
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994717/
https://www.ncbi.nlm.nih.gov/pubmed/33767200
http://dx.doi.org/10.1038/s41541-021-00313-8
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