Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas

Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative. However, complete resection may not be an option for patients with succinate dehydrogenase subunit A-D (SDHx) mutations. SDHx mutations are...

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Detalles Bibliográficos
Autores principales: Matlac, Dieter M., Hadrava Vanova, Katerina, Bechmann, Nicole, Richter, Susan, Folberth, Julica, Ghayee, Hans K., Ge, Guang-Bo, Abunimer, Luma, Wesley, Robert, Aherrahrou, Redouane, Dona, Margo, Martínez-Montes, Ángel M., Calsina, Bruna, Merino, Maria J., Schwaninger, Markus, Deen, Peter M. T., Zhuang, Zhengping, Neuzil, Jiri, Pacak, Karel, Lehnert, Hendrik, Fliedner, Stephanie M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994772/
https://www.ncbi.nlm.nih.gov/pubmed/33776908
http://dx.doi.org/10.3389/fendo.2021.589451

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