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Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation
Ultrasonication to supersaturated protein solutions forcibly forms amyloid fibrils, thereby allowing the early-stage diagnosis for amyloidoses. Previously, we constructed a high-throughput sonoreactor to investigate features of the amyloid-fibril nucleation. Although the instrument substantiated the...
Autores principales: | Nakajima, Kichitaro, Noi, Kentaro, Yamaguchi, Keiichi, So, Masatomo, Ikenaka, Kensuke, Mochizuki, Hideki, Ogi, Hirotsugu, Goto, Yuji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994783/ https://www.ncbi.nlm.nih.gov/pubmed/33770746 http://dx.doi.org/10.1016/j.ultsonch.2021.105508 |
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