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Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

TEM-1 β-lactamase degrades β-lactam antibiotics with a strong preference for penicillins. Sequence reconstruction studies indicate that it evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency. This generalist to specialist conversion involved more t...

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Detalles Bibliográficos
Autores principales:	Modi, Tushar, Risso, Valeria A., Martinez-Rodriguez, Sergio, Gavira, Jose A., Mebrat, Mubark D., Van Horn, Wade D., Sanchez-Ruiz, Jose M., Banu Ozkan, S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994827/ https://www.ncbi.nlm.nih.gov/pubmed/33767175 http://dx.doi.org/10.1038/s41467-021-22089-0

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