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Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers

While the ongoing COVID‐19 pandemic affirms an urgent global need for effective vaccines as second and third infection waves are spreading worldwide and generating new mutant virus strains, it has also revealed the importance of mitigating the transmission of SARS‐CoV‐2 through the introduction of r...

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Autores principales: Peddinti, Bharadwaja S. T., Downs, Sierra N., Yan, Jiaqi, Smith, Steven D., Ghiladi, Reza A., Mhetar, Vijay, Tocchetto, Roger, Griffiths, Anthony, Scholle, Frank, Spontak, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994973/
https://www.ncbi.nlm.nih.gov/pubmed/34105286
http://dx.doi.org/10.1002/advs.202003503
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author Peddinti, Bharadwaja S. T.
Downs, Sierra N.
Yan, Jiaqi
Smith, Steven D.
Ghiladi, Reza A.
Mhetar, Vijay
Tocchetto, Roger
Griffiths, Anthony
Scholle, Frank
Spontak, Richard J.
author_facet Peddinti, Bharadwaja S. T.
Downs, Sierra N.
Yan, Jiaqi
Smith, Steven D.
Ghiladi, Reza A.
Mhetar, Vijay
Tocchetto, Roger
Griffiths, Anthony
Scholle, Frank
Spontak, Richard J.
author_sort Peddinti, Bharadwaja S. T.
collection PubMed
description While the ongoing COVID‐19 pandemic affirms an urgent global need for effective vaccines as second and third infection waves are spreading worldwide and generating new mutant virus strains, it has also revealed the importance of mitigating the transmission of SARS‐CoV‐2 through the introduction of restrictive social practices. Here, it is demonstrated that an architecturally‐ and chemically‐diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces. Operating on a dramatic pH‐drop mechanism along the polymer/pathogen interface, polymers of this archetype inactivate the SARS‐CoV‐2 virus, as well as a human coronavirus surrogate (HCoV‐229E), to the minimum detection limit within minutes. Application of these anionic polymers to frequently touched surfaces in medical, educational, and public‐transportation facilities, or personal protection equipment, can provide rapid and repetitive protection without detrimental health or environmental complications.
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spelling pubmed-79949732021-03-26 Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers Peddinti, Bharadwaja S. T. Downs, Sierra N. Yan, Jiaqi Smith, Steven D. Ghiladi, Reza A. Mhetar, Vijay Tocchetto, Roger Griffiths, Anthony Scholle, Frank Spontak, Richard J. Adv Sci (Weinh) Communications While the ongoing COVID‐19 pandemic affirms an urgent global need for effective vaccines as second and third infection waves are spreading worldwide and generating new mutant virus strains, it has also revealed the importance of mitigating the transmission of SARS‐CoV‐2 through the introduction of restrictive social practices. Here, it is demonstrated that an architecturally‐ and chemically‐diverse family of nanostructured anionic polymers yield a rapid and continuous disinfecting alternative to inactivate coronaviruses and prevent their transmission from contact with contaminated surfaces. Operating on a dramatic pH‐drop mechanism along the polymer/pathogen interface, polymers of this archetype inactivate the SARS‐CoV‐2 virus, as well as a human coronavirus surrogate (HCoV‐229E), to the minimum detection limit within minutes. Application of these anionic polymers to frequently touched surfaces in medical, educational, and public‐transportation facilities, or personal protection equipment, can provide rapid and repetitive protection without detrimental health or environmental complications. John Wiley and Sons Inc. 2021-03-08 /pmc/articles/PMC7994973/ /pubmed/34105286 http://dx.doi.org/10.1002/advs.202003503 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Peddinti, Bharadwaja S. T.
Downs, Sierra N.
Yan, Jiaqi
Smith, Steven D.
Ghiladi, Reza A.
Mhetar, Vijay
Tocchetto, Roger
Griffiths, Anthony
Scholle, Frank
Spontak, Richard J.
Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers
title Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers
title_full Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers
title_fullStr Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers
title_full_unstemmed Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers
title_short Rapid and Repetitive Inactivation of SARS‐CoV‐2 and Human Coronavirus on Self‐Disinfecting Anionic Polymers
title_sort rapid and repetitive inactivation of sars‐cov‐2 and human coronavirus on self‐disinfecting anionic polymers
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7994973/
https://www.ncbi.nlm.nih.gov/pubmed/34105286
http://dx.doi.org/10.1002/advs.202003503
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