Generation of enzymatically competent SARS‐CoV‐2 decoy receptor ACE2‐Fc in glycoengineered Nicotiana benthamiana

Human angiotensin‐converting enzyme 2 (ACE2) is the primary host cell receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) binding and cell entry. Administration of high concentrations of soluble ACE2 can be utilized as a decoy to block the interaction of the virus with cellular...

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Detalles Bibliográficos
Autores principales: Castilho, Alexandra, Schwestka, Jennifer, Kienzl, Nikolaus F., Vavra, Ulrike, Grünwald‐Gruber, Clemens, Izadi, Shiva, Hiremath, Chaitra, Niederhöfer, Janine, Laurent, Elisabeth, Monteil, Vanessa, Mirazimi, Ali, Wirnsberger, Gerald, Stadlmann, Johannes, Stöger, Eva, Mach, Lukas, Strasser, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995010/
https://www.ncbi.nlm.nih.gov/pubmed/33481336
http://dx.doi.org/10.1002/biot.202000566

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