Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell lines, PDXs, and patients with acute myeloid leukemia (AML) harboring an IDH mutation displayed an enhanced mitoch...

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Detalles Bibliográficos
Autores principales: Stuani, Lucille, Sabatier, Marie, Saland, Estelle, Cognet, Guillaume, Poupin, Nathalie, Bosc, Claudie, Castelli, Florence A., Gales, Lara, Turtoi, Evgenia, Montersino, Camille, Farge, Thomas, Boet, Emeline, Broin, Nicolas, Larrue, Clément, Baran, Natalia, Cissé, Madi Y., Conti, Marc, Loric, Sylvain, Kaoma, Tony, Hucteau, Alexis, Zavoriti, Aliki, Sahal, Ambrine, Mouchel, Pierre-Luc, Gotanègre, Mathilde, Cassan, Cédric, Fernando, Laurent, Wang, Feng, Hosseini, Mohsen, Chu-Van, Emeline, Le Cam, Laurent, Carroll, Martin, Selak, Mary A., Vey, Norbert, Castellano, Rémy, Fenaille, François, Turtoi, Andrei, Cazals, Guillaume, Bories, Pierre, Gibon, Yves, Nicolay, Brandon, Ronseaux, Sébastien, Marszalek, Joseph R., Takahashi, Koichi, DiNardo, Courtney D., Konopleva, Marina, Pancaldi, Véra, Collette, Yves, Bellvert, Floriant, Jourdan, Fabien, Linares, Laetitia K., Récher, Christian, Portais, Jean-Charles, Sarry, Jean-Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995203/
https://www.ncbi.nlm.nih.gov/pubmed/33760042
http://dx.doi.org/10.1084/jem.20200924

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