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Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease

BACKGROUND: In the absence of echocardiography, identification of cardiomegaly via thoracic radiography is a necessary criterion for classification of disease severity in dogs with myxomatous mitral valve disease (MMVD). OBJECTIVE: Modified‐vertebral left atrial size (M‐VLAS) facilitates objective r...

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Autores principales: Lam, Christopher, Gavaghan, Brad J., Meyers, Fiona E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995357/
https://www.ncbi.nlm.nih.gov/pubmed/33634912
http://dx.doi.org/10.1111/jvim.16073
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author Lam, Christopher
Gavaghan, Brad J.
Meyers, Fiona E.
author_facet Lam, Christopher
Gavaghan, Brad J.
Meyers, Fiona E.
author_sort Lam, Christopher
collection PubMed
description BACKGROUND: In the absence of echocardiography, identification of cardiomegaly via thoracic radiography is a necessary criterion for classification of disease severity in dogs with myxomatous mitral valve disease (MMVD). OBJECTIVE: Modified‐vertebral left atrial size (M‐VLAS) facilitates objective radiographic assessment of the left atrium (LA) in 2 dimensions and identifies LA enlargement more accurately than existing methods. ANIMALS: Sixty‐four dogs with various stages of MMVD and 6 control healthy dogs. METHODS: Retrospective case–control study. Medical records were searched for dogs with varying severity of MMVD. Modified‐vertebral left atrial size, vertebral left atrial size (VLAS), vertebral heart size (VHS), and radiographic left atrial dimension (RLAD) were measured from thoracic radiographs and compared with echocardiographically derived measurements. RESULTS: Positive correlation to LA/Ao was identified for M‐VLAS (r = 0.77, P < .001), VLAS (r = 0.76, P < .001), RLAD (r = 0.75, P < .001), and VHS (r = 0.67, P < .001). Receiver operating characteristic analyzes provided an area under the curve of 0.97 (95% CI, 0.94‐1.00) for M‐VLAS, which was superior to VHS (0.90, 95% CI, 0.94‐1.00, P = .03) in identifying dogs with LA/Ao ≥1.6. A cut‐off value of ≥3.4 vertebrae using M‐VLAS provided 92.7% sensitivity and 93.1% specificity in predicting LA enlargement. CONCLUSIONS AND CLINICAL IMPORTANCE: M‐VLAS, which is superior to VHS, offers an accurate and repeatable way to radiographically identify LA enlargement in dogs with MMVD.
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spelling pubmed-79953572021-03-30 Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease Lam, Christopher Gavaghan, Brad J. Meyers, Fiona E. J Vet Intern Med SMALL ANIMAL BACKGROUND: In the absence of echocardiography, identification of cardiomegaly via thoracic radiography is a necessary criterion for classification of disease severity in dogs with myxomatous mitral valve disease (MMVD). OBJECTIVE: Modified‐vertebral left atrial size (M‐VLAS) facilitates objective radiographic assessment of the left atrium (LA) in 2 dimensions and identifies LA enlargement more accurately than existing methods. ANIMALS: Sixty‐four dogs with various stages of MMVD and 6 control healthy dogs. METHODS: Retrospective case–control study. Medical records were searched for dogs with varying severity of MMVD. Modified‐vertebral left atrial size, vertebral left atrial size (VLAS), vertebral heart size (VHS), and radiographic left atrial dimension (RLAD) were measured from thoracic radiographs and compared with echocardiographically derived measurements. RESULTS: Positive correlation to LA/Ao was identified for M‐VLAS (r = 0.77, P < .001), VLAS (r = 0.76, P < .001), RLAD (r = 0.75, P < .001), and VHS (r = 0.67, P < .001). Receiver operating characteristic analyzes provided an area under the curve of 0.97 (95% CI, 0.94‐1.00) for M‐VLAS, which was superior to VHS (0.90, 95% CI, 0.94‐1.00, P = .03) in identifying dogs with LA/Ao ≥1.6. A cut‐off value of ≥3.4 vertebrae using M‐VLAS provided 92.7% sensitivity and 93.1% specificity in predicting LA enlargement. CONCLUSIONS AND CLINICAL IMPORTANCE: M‐VLAS, which is superior to VHS, offers an accurate and repeatable way to radiographically identify LA enlargement in dogs with MMVD. John Wiley & Sons, Inc. 2021-02-26 2021 /pmc/articles/PMC7995357/ /pubmed/33634912 http://dx.doi.org/10.1111/jvim.16073 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle SMALL ANIMAL
Lam, Christopher
Gavaghan, Brad J.
Meyers, Fiona E.
Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease
title Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease
title_full Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease
title_fullStr Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease
title_full_unstemmed Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease
title_short Radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease
title_sort radiographic quantification of left atrial size in dogs with myxomatous mitral valve disease
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995357/
https://www.ncbi.nlm.nih.gov/pubmed/33634912
http://dx.doi.org/10.1111/jvim.16073
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