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Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study

BACKGROUND: Proteinuria is an independent risk factor for morbidity and mortality in dogs. An association between proteinuria and gallbladder mucocele formation in dogs is unknown. OBJECTIVE: Determine if gallbladder mucocele formation or clinicopathologic comorbidities are associated with proteinur...

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Autores principales: Lindaberry, Crystal, Vaden, Shelly, Aicher, Kathleen M., Seiler, Gabriela, Robertson, James, Cianciolo, Rachel, Yang, Ching, Gookin, Jody L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995360/
https://www.ncbi.nlm.nih.gov/pubmed/33547696
http://dx.doi.org/10.1111/jvim.16051
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author Lindaberry, Crystal
Vaden, Shelly
Aicher, Kathleen M.
Seiler, Gabriela
Robertson, James
Cianciolo, Rachel
Yang, Ching
Gookin, Jody L.
author_facet Lindaberry, Crystal
Vaden, Shelly
Aicher, Kathleen M.
Seiler, Gabriela
Robertson, James
Cianciolo, Rachel
Yang, Ching
Gookin, Jody L.
author_sort Lindaberry, Crystal
collection PubMed
description BACKGROUND: Proteinuria is an independent risk factor for morbidity and mortality in dogs. An association between proteinuria and gallbladder mucocele formation in dogs is unknown. OBJECTIVE: Determine if gallbladder mucocele formation or clinicopathologic comorbidities are associated with proteinuria. ANIMALS: Twenty‐five dogs with mucocele formation and 25 breed and age‐matched control dogs from a prior study. METHODS: Retrospective case control study. Proteinuria defined by calculated urine dipstick protein concentration (mg/mL) to urine specific gravity (USG) ratio. Clinicopathologic findings, postcosyntropin cortisol concentration, thyroid function profile, and illness severity score were recorded. RESULTS: Median urine dipstick protein concentration to USG ratio and number of dogs having a ratio ≥1.5 were significantly higher for dogs with mucocele formation compared to control dogs. Proteinuria was not significantly associated with CBC or serum biochemistry profile abnormalities but increased in relation to severity of illness. CONCLUSIONS AND CLINICAL IMPORTANCE: Gallbladder mucocele formation is significantly associated with proteinuria in dogs. Diagnosis and treatment of proteinuria in dogs with mucocele formation might minimize long term kidney morbidity in these patients.
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spelling pubmed-79953602021-03-30 Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study Lindaberry, Crystal Vaden, Shelly Aicher, Kathleen M. Seiler, Gabriela Robertson, James Cianciolo, Rachel Yang, Ching Gookin, Jody L. J Vet Intern Med SMALL ANIMAL BACKGROUND: Proteinuria is an independent risk factor for morbidity and mortality in dogs. An association between proteinuria and gallbladder mucocele formation in dogs is unknown. OBJECTIVE: Determine if gallbladder mucocele formation or clinicopathologic comorbidities are associated with proteinuria. ANIMALS: Twenty‐five dogs with mucocele formation and 25 breed and age‐matched control dogs from a prior study. METHODS: Retrospective case control study. Proteinuria defined by calculated urine dipstick protein concentration (mg/mL) to urine specific gravity (USG) ratio. Clinicopathologic findings, postcosyntropin cortisol concentration, thyroid function profile, and illness severity score were recorded. RESULTS: Median urine dipstick protein concentration to USG ratio and number of dogs having a ratio ≥1.5 were significantly higher for dogs with mucocele formation compared to control dogs. Proteinuria was not significantly associated with CBC or serum biochemistry profile abnormalities but increased in relation to severity of illness. CONCLUSIONS AND CLINICAL IMPORTANCE: Gallbladder mucocele formation is significantly associated with proteinuria in dogs. Diagnosis and treatment of proteinuria in dogs with mucocele formation might minimize long term kidney morbidity in these patients. John Wiley & Sons, Inc. 2021-02-06 2021 /pmc/articles/PMC7995360/ /pubmed/33547696 http://dx.doi.org/10.1111/jvim.16051 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Lindaberry, Crystal
Vaden, Shelly
Aicher, Kathleen M.
Seiler, Gabriela
Robertson, James
Cianciolo, Rachel
Yang, Ching
Gookin, Jody L.
Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study
title Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study
title_full Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study
title_fullStr Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study
title_full_unstemmed Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study
title_short Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study
title_sort proteinuria in dogs with gallbladder mucocele formation: a retrospective case control study
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995360/
https://www.ncbi.nlm.nih.gov/pubmed/33547696
http://dx.doi.org/10.1111/jvim.16051
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