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Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats

BACKGROUND: There are no commercially available handheld blood creatinine analyzers validated in goats. OBJECTIVES: The objective of the study was to validate the accuracy of a handheld point‐of‐care (POC) analyzer (Nova StatSensor) for quantifying blood creatinine concentration in goats. A secondar...

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Autores principales: Boileau, Melanie J, Wagner, Leslie, Taylor, Jared D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995365/
https://www.ncbi.nlm.nih.gov/pubmed/33625770
http://dx.doi.org/10.1111/jvim.16059
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author Boileau, Melanie J
Wagner, Leslie
Taylor, Jared D
author_facet Boileau, Melanie J
Wagner, Leslie
Taylor, Jared D
author_sort Boileau, Melanie J
collection PubMed
description BACKGROUND: There are no commercially available handheld blood creatinine analyzers validated in goats. OBJECTIVES: The objective of the study was to validate the accuracy of a handheld point‐of‐care (POC) analyzer (Nova StatSensor) for quantifying blood creatinine concentration in goats. A secondary objective was to compare this POC against a chemistry analyzer to classify goats as normal or having mild or moderate azotemia. ANIMALS: Sixty‐three goats admitted to a referral hospital. METHODS: Cross‐sectional study. Venous blood was obtained, and creatinine concentration was measured by the POC in duplicate. Plasma was submitted for creatinine determination via the chemistry analyzer (gold standard). RESULTS: A total of 101 blood samples were collected from 63 goats. There was high repeatability for creatinine concentrations obtained by the POC (adjusted R (2) = .97, P < .0001). Correlation of POC concentrations with those reported by the chemistry analyzer was moderate (adjusted R (2) = .57, P < .0001). When correctly categorizing goats with mild azotemia, the POC demonstrated a sensitivity of 73.3% and a specificity of 88.3%. For moderate to severe azotemia, the POC had a sensitivity of 75.0% and specificity of 97.5%. CONCLUSION AND CLINICAL IMPORTANCE: The Nova StatSensor POC provided above average accuracy for measuring blood creatinine concentration in goats compared with the gold standard test.
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spelling pubmed-79953652021-03-30 Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats Boileau, Melanie J Wagner, Leslie Taylor, Jared D J Vet Intern Med FOOD AND FIBER BACKGROUND: There are no commercially available handheld blood creatinine analyzers validated in goats. OBJECTIVES: The objective of the study was to validate the accuracy of a handheld point‐of‐care (POC) analyzer (Nova StatSensor) for quantifying blood creatinine concentration in goats. A secondary objective was to compare this POC against a chemistry analyzer to classify goats as normal or having mild or moderate azotemia. ANIMALS: Sixty‐three goats admitted to a referral hospital. METHODS: Cross‐sectional study. Venous blood was obtained, and creatinine concentration was measured by the POC in duplicate. Plasma was submitted for creatinine determination via the chemistry analyzer (gold standard). RESULTS: A total of 101 blood samples were collected from 63 goats. There was high repeatability for creatinine concentrations obtained by the POC (adjusted R (2) = .97, P < .0001). Correlation of POC concentrations with those reported by the chemistry analyzer was moderate (adjusted R (2) = .57, P < .0001). When correctly categorizing goats with mild azotemia, the POC demonstrated a sensitivity of 73.3% and a specificity of 88.3%. For moderate to severe azotemia, the POC had a sensitivity of 75.0% and specificity of 97.5%. CONCLUSION AND CLINICAL IMPORTANCE: The Nova StatSensor POC provided above average accuracy for measuring blood creatinine concentration in goats compared with the gold standard test. John Wiley & Sons, Inc. 2021-02-24 2021 /pmc/articles/PMC7995365/ /pubmed/33625770 http://dx.doi.org/10.1111/jvim.16059 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle FOOD AND FIBER
Boileau, Melanie J
Wagner, Leslie
Taylor, Jared D
Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
title Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
title_full Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
title_fullStr Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
title_full_unstemmed Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
title_short Evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
title_sort evaluation of the accuracy of an electronic point‐of‐care analyzer to quantify blood creatinine concentration in goats
topic FOOD AND FIBER
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995365/
https://www.ncbi.nlm.nih.gov/pubmed/33625770
http://dx.doi.org/10.1111/jvim.16059
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