In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect

BACKGROUND: Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against COVID-19. Sequences of the main antigenic proteins in t...

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Autores principales: Haddad-Boubaker, Sondes, Othman, Houcemeddine, Touati, Rabeb, Ayouni, Kaouther, Lakhal, Marwa, Ben Mustapha, Imen, Ghedira, Kais, Kharrat, Maher, Triki, Henda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995392/
https://www.ncbi.nlm.nih.gov/pubmed/33771096
http://dx.doi.org/10.1186/s12859-021-04045-3
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author Haddad-Boubaker, Sondes
Othman, Houcemeddine
Touati, Rabeb
Ayouni, Kaouther
Lakhal, Marwa
Ben Mustapha, Imen
Ghedira, Kais
Kharrat, Maher
Triki, Henda
author_facet Haddad-Boubaker, Sondes
Othman, Houcemeddine
Touati, Rabeb
Ayouni, Kaouther
Lakhal, Marwa
Ben Mustapha, Imen
Ghedira, Kais
Kharrat, Maher
Triki, Henda
author_sort Haddad-Boubaker, Sondes
collection PubMed
description BACKGROUND: Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against COVID-19. Sequences of the main antigenic proteins in the investigated vaccines and SARS-CoV-2 proteins were compared to identify similar patterns. The immunogenic effect of identified segments was, then, assessed using a combination of structural and antigenicity prediction tools. RESULTS: A total of 14 highly similar segments were identified in the investigated vaccines. Structural and antigenicity prediction analysis showed that, among the identified patterns, three segments in Hepatitis B, Tetanus, and Measles proteins presented antigenic properties that can induce putative protective effect against COVID-19. CONCLUSIONS: Our results suggest a possible protective effect of HBV, Tetanus and Measles vaccines against COVID-19, which may explain the variation of the disease severity among regions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-021-04045-3.
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spelling pubmed-79953922021-03-26 In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect Haddad-Boubaker, Sondes Othman, Houcemeddine Touati, Rabeb Ayouni, Kaouther Lakhal, Marwa Ben Mustapha, Imen Ghedira, Kais Kharrat, Maher Triki, Henda BMC Bioinformatics Research Article BACKGROUND: Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against COVID-19. Sequences of the main antigenic proteins in the investigated vaccines and SARS-CoV-2 proteins were compared to identify similar patterns. The immunogenic effect of identified segments was, then, assessed using a combination of structural and antigenicity prediction tools. RESULTS: A total of 14 highly similar segments were identified in the investigated vaccines. Structural and antigenicity prediction analysis showed that, among the identified patterns, three segments in Hepatitis B, Tetanus, and Measles proteins presented antigenic properties that can induce putative protective effect against COVID-19. CONCLUSIONS: Our results suggest a possible protective effect of HBV, Tetanus and Measles vaccines against COVID-19, which may explain the variation of the disease severity among regions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12859-021-04045-3. BioMed Central 2021-03-26 /pmc/articles/PMC7995392/ /pubmed/33771096 http://dx.doi.org/10.1186/s12859-021-04045-3 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Haddad-Boubaker, Sondes
Othman, Houcemeddine
Touati, Rabeb
Ayouni, Kaouther
Lakhal, Marwa
Ben Mustapha, Imen
Ghedira, Kais
Kharrat, Maher
Triki, Henda
In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect
title In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect
title_full In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect
title_fullStr In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect
title_full_unstemmed In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect
title_short In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect
title_sort in silico comparative study of sars-cov-2 proteins and antigenic proteins in bcg, opv, mmr and other vaccines: evidence of a possible putative protective effect
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995392/
https://www.ncbi.nlm.nih.gov/pubmed/33771096
http://dx.doi.org/10.1186/s12859-021-04045-3
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