Cargando…

Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs

BACKGROUND: Most dogs with sinonasal tumors (SNT) treated with radiation therapy (RT) died because of local disease progression. HYPOTHESIS/OBJECTIVES: Our hypothesis is that the majority of local failure and residual disease would occur within the radiation field. ANIMALS: Twenty‐two dogs with SNT...

Descripción completa

Detalles Bibliográficos
Autores principales: Poirier, Valerie J., Koh, Ethel S. Y., Darko, Johnson, Fleck, Andre, Pinard, Christopher, Vail, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995431/
https://www.ncbi.nlm.nih.gov/pubmed/33660342
http://dx.doi.org/10.1111/jvim.16076
_version_ 1783669918378491904
author Poirier, Valerie J.
Koh, Ethel S. Y.
Darko, Johnson
Fleck, Andre
Pinard, Christopher
Vail, David M.
author_facet Poirier, Valerie J.
Koh, Ethel S. Y.
Darko, Johnson
Fleck, Andre
Pinard, Christopher
Vail, David M.
author_sort Poirier, Valerie J.
collection PubMed
description BACKGROUND: Most dogs with sinonasal tumors (SNT) treated with radiation therapy (RT) died because of local disease progression. HYPOTHESIS/OBJECTIVES: Our hypothesis is that the majority of local failure and residual disease would occur within the radiation field. ANIMALS: Twenty‐two dogs with SNT treated with RT. METHODS: Retrospective cohort study. Inclusion criteria: dogs with SNT receiving 10 daily fractions of 4.2 Gy with intensity modulated radiation therapy (IMRT)/image guided radiation therapy (IGRT) and follow‐up cone beam computed tomography (CBCT). Each CBCT was registered with the original radiation planning CT and the gross tumor volume (GTV) contoured. The GTV was classified as residual (GTVr) or a failure (GTVf). The dose statistic for each GTV was calculated with the original IMRT plan. For GTVf, failures were classified as “in‐field,” “marginal,” or “out‐field” if at least 95, 20‐95, or less than 20% of the volume of failure was within 95% (D95) of the total prescription dose, respectively. RESULTS: There were 52 follow‐up CBCT/CTs. Overall there was a GTVr for 20 dogs and GTVf for 16 dogs. The majority of GTVr volume was within the original GTV. GTVf analysis showed that 75% (12/16) were “in‐field,” 19% (3/16) were “marginal” and 6% (1/16) were “out‐field.” CONCLUSION AND CLINICAL IMPORTANCE: In‐field failures are the main pattern for local recurrence, and there is evidence of radioresistant subvolumes within the GTV.
format Online
Article
Text
id pubmed-7995431
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-79954312021-03-30 Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs Poirier, Valerie J. Koh, Ethel S. Y. Darko, Johnson Fleck, Andre Pinard, Christopher Vail, David M. J Vet Intern Med SMALL ANIMAL BACKGROUND: Most dogs with sinonasal tumors (SNT) treated with radiation therapy (RT) died because of local disease progression. HYPOTHESIS/OBJECTIVES: Our hypothesis is that the majority of local failure and residual disease would occur within the radiation field. ANIMALS: Twenty‐two dogs with SNT treated with RT. METHODS: Retrospective cohort study. Inclusion criteria: dogs with SNT receiving 10 daily fractions of 4.2 Gy with intensity modulated radiation therapy (IMRT)/image guided radiation therapy (IGRT) and follow‐up cone beam computed tomography (CBCT). Each CBCT was registered with the original radiation planning CT and the gross tumor volume (GTV) contoured. The GTV was classified as residual (GTVr) or a failure (GTVf). The dose statistic for each GTV was calculated with the original IMRT plan. For GTVf, failures were classified as “in‐field,” “marginal,” or “out‐field” if at least 95, 20‐95, or less than 20% of the volume of failure was within 95% (D95) of the total prescription dose, respectively. RESULTS: There were 52 follow‐up CBCT/CTs. Overall there was a GTVr for 20 dogs and GTVf for 16 dogs. The majority of GTVr volume was within the original GTV. GTVf analysis showed that 75% (12/16) were “in‐field,” 19% (3/16) were “marginal” and 6% (1/16) were “out‐field.” CONCLUSION AND CLINICAL IMPORTANCE: In‐field failures are the main pattern for local recurrence, and there is evidence of radioresistant subvolumes within the GTV. John Wiley & Sons, Inc. 2021-03-04 2021 /pmc/articles/PMC7995431/ /pubmed/33660342 http://dx.doi.org/10.1111/jvim.16076 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle SMALL ANIMAL
Poirier, Valerie J.
Koh, Ethel S. Y.
Darko, Johnson
Fleck, Andre
Pinard, Christopher
Vail, David M.
Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
title Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
title_full Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
title_fullStr Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
title_full_unstemmed Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
title_short Patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
title_sort patterns of local residual disease and local failure after intensity modulated/image guided radiation therapy for sinonasal tumors in dogs
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995431/
https://www.ncbi.nlm.nih.gov/pubmed/33660342
http://dx.doi.org/10.1111/jvim.16076
work_keys_str_mv AT poiriervaleriej patternsoflocalresidualdiseaseandlocalfailureafterintensitymodulatedimageguidedradiationtherapyforsinonasaltumorsindogs
AT kohethelsy patternsoflocalresidualdiseaseandlocalfailureafterintensitymodulatedimageguidedradiationtherapyforsinonasaltumorsindogs
AT darkojohnson patternsoflocalresidualdiseaseandlocalfailureafterintensitymodulatedimageguidedradiationtherapyforsinonasaltumorsindogs
AT fleckandre patternsoflocalresidualdiseaseandlocalfailureafterintensitymodulatedimageguidedradiationtherapyforsinonasaltumorsindogs
AT pinardchristopher patternsoflocalresidualdiseaseandlocalfailureafterintensitymodulatedimageguidedradiationtherapyforsinonasaltumorsindogs
AT vaildavidm patternsoflocalresidualdiseaseandlocalfailureafterintensitymodulatedimageguidedradiationtherapyforsinonasaltumorsindogs