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Globe salvage treatment in group D and group E retinoblastoma

Importance: Globe salvage marks the treatment success of retinoblastoma. Background: To evaluate four treatment strategies in group D and group E retinoblastoma. Design: Retrospective case series in a tertiary hospital. Participants: 81 patients with Group D and Group E retinoblastoma. Methods: Part...

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Autores principales: Khaqan, Hussain Ahmad, Anil, Rahul Rachwani, Rocha de Lossada, Carlos, Martín, Francisco Zamorano, Lorente, María García, Pennisi, Flavia, Bonzano, Chiara, Borroni, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Romanian Society of Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995513/
https://www.ncbi.nlm.nih.gov/pubmed/33817429
http://dx.doi.org/10.22336/rjo.2021.5
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author Khaqan, Hussain Ahmad
Anil, Rahul Rachwani
Rocha de Lossada, Carlos
Martín, Francisco Zamorano
Lorente, María García
Pennisi, Flavia
Bonzano, Chiara
Borroni, Davide
author_facet Khaqan, Hussain Ahmad
Anil, Rahul Rachwani
Rocha de Lossada, Carlos
Martín, Francisco Zamorano
Lorente, María García
Pennisi, Flavia
Bonzano, Chiara
Borroni, Davide
author_sort Khaqan, Hussain Ahmad
collection PubMed
description Importance: Globe salvage marks the treatment success of retinoblastoma. Background: To evaluate four treatment strategies in group D and group E retinoblastoma. Design: Retrospective case series in a tertiary hospital. Participants: 81 patients with Group D and Group E retinoblastoma. Methods: Participants were divided into four sets. In set I, eyes received primary intravenous chemotherapy (IVC), cryotherapy (CT), laser therapy (LT) and Intravitreal Chemotherapy with Melphalan (IViC). In set II, primary IVC was combined with second line IVC, CT, LT and IVT-M. Set III eyes received primary IVC and Intra-arterial chemotherapy (IAC), CT, LT and IViC. Set IV eyes received IAC, CT, LT and IViC. Treatment failure was defined as inadequate response during or after IVC or IAC. Main Outcome Measures: globe salvage and enucleation rates. Results: 52 eyes were included in group D and 29 in group E. In group D, globe salvage was obtained in 8 out of 11 eyes in Set I, 13 out of 19 eyes in set II, 5 out 6 eyes in set III, and 13 out of 16 eyes in set IV. In group E, enucleation was performed in 17 eyes. Global salvage was obtained in 0 out of 2 eyes in set I, 2 out of 3 eyes in set II, 3 out of 5 in set III, and in 1 out of 2 eyes in set IV. Conclusions: IVC with adjuvant IAC, LT, CT and IViC has shown favorable results as a treatment method for group D and group E retinoblastoma.
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spelling pubmed-79955132021-04-01 Globe salvage treatment in group D and group E retinoblastoma Khaqan, Hussain Ahmad Anil, Rahul Rachwani Rocha de Lossada, Carlos Martín, Francisco Zamorano Lorente, María García Pennisi, Flavia Bonzano, Chiara Borroni, Davide Rom J Ophthalmol General Articles Importance: Globe salvage marks the treatment success of retinoblastoma. Background: To evaluate four treatment strategies in group D and group E retinoblastoma. Design: Retrospective case series in a tertiary hospital. Participants: 81 patients with Group D and Group E retinoblastoma. Methods: Participants were divided into four sets. In set I, eyes received primary intravenous chemotherapy (IVC), cryotherapy (CT), laser therapy (LT) and Intravitreal Chemotherapy with Melphalan (IViC). In set II, primary IVC was combined with second line IVC, CT, LT and IVT-M. Set III eyes received primary IVC and Intra-arterial chemotherapy (IAC), CT, LT and IViC. Set IV eyes received IAC, CT, LT and IViC. Treatment failure was defined as inadequate response during or after IVC or IAC. Main Outcome Measures: globe salvage and enucleation rates. Results: 52 eyes were included in group D and 29 in group E. In group D, globe salvage was obtained in 8 out of 11 eyes in Set I, 13 out of 19 eyes in set II, 5 out 6 eyes in set III, and 13 out of 16 eyes in set IV. In group E, enucleation was performed in 17 eyes. Global salvage was obtained in 0 out of 2 eyes in set I, 2 out of 3 eyes in set II, 3 out of 5 in set III, and in 1 out of 2 eyes in set IV. Conclusions: IVC with adjuvant IAC, LT, CT and IViC has shown favorable results as a treatment method for group D and group E retinoblastoma. Romanian Society of Ophthalmology 2021 /pmc/articles/PMC7995513/ /pubmed/33817429 http://dx.doi.org/10.22336/rjo.2021.5 Text en ©Romanian Society of Ophthalmology https://creativecommons.org/licenses/by/2.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle General Articles
Khaqan, Hussain Ahmad
Anil, Rahul Rachwani
Rocha de Lossada, Carlos
Martín, Francisco Zamorano
Lorente, María García
Pennisi, Flavia
Bonzano, Chiara
Borroni, Davide
Globe salvage treatment in group D and group E retinoblastoma
title Globe salvage treatment in group D and group E retinoblastoma
title_full Globe salvage treatment in group D and group E retinoblastoma
title_fullStr Globe salvage treatment in group D and group E retinoblastoma
title_full_unstemmed Globe salvage treatment in group D and group E retinoblastoma
title_short Globe salvage treatment in group D and group E retinoblastoma
title_sort globe salvage treatment in group d and group e retinoblastoma
topic General Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995513/
https://www.ncbi.nlm.nih.gov/pubmed/33817429
http://dx.doi.org/10.22336/rjo.2021.5
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