HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Heterozygous gain-of-function (GOF) mutations of hypoxia-inducible factor 2α (HIF2A), a key hypoxia-sensing regulator, are associated with erythrocytosis, thrombosis, and vascular complications that account for morbidity and mortality of patients. We demonstrated that the vascular pathology of HIF2A...

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Detalles Bibliográficos
Autores principales: Chan, Xin Yi, Volkova, Eugenia, Eoh, Joon, Black, Rebecca, Fang, Lilly, Gorashi, Rayyan, Song, Jihyun, Wang, Jing, Elliott, Morgan B., Barreto-Ortiz, Sebastian F., Chen, James, Lin, Brian L., Santhanam, Lakshmi, Cheng, Linzhao, Lee, Frank S., Prchal, Josef T., Gerecht, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995528/
https://www.ncbi.nlm.nih.gov/pubmed/33796838
http://dx.doi.org/10.1016/j.isci.2021.102246

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