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Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report
BACKGROUND: Paraneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diagnosis of breast cancer and small-cell lung cancer. It is uncommon and typically...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995578/ https://www.ncbi.nlm.nih.gov/pubmed/33766120 http://dx.doi.org/10.1186/s13256-021-02727-3 |
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author | Kwatra, Vineet Charakidis, Michail Karanth, Narayan V. |
author_facet | Kwatra, Vineet Charakidis, Michail Karanth, Narayan V. |
author_sort | Kwatra, Vineet |
collection | PubMed |
description | BACKGROUND: Paraneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diagnosis of breast cancer and small-cell lung cancer. It is uncommon and typically associated with stiff-person syndrome, of which 90% of patients are eventually diagnosed with breast cancer. CASE PRESENTATION: We present a case of a 47-year-old Caucasian woman with metastatic hormone receptor-positive breast cancer who developed bilateral facial nerve palsy while on treatment with nab-paclitaxel. The patient was found to have anti-amphiphysin antibody in the serum and cerebrospinal fluid. She was treated with methylprednisolone and intravenous immunoglobulin, which resulted in partial improvement in her facial nerve palsy. CONCLUSIONS: This case highlights a rare presentation of bilateral facial nerve palsy that likely related to paraneoplastic syndrome associated with the presence of anti-amphiphysin antibody. |
format | Online Article Text |
id | pubmed-7995578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-79955782021-03-26 Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report Kwatra, Vineet Charakidis, Michail Karanth, Narayan V. J Med Case Rep Case Report BACKGROUND: Paraneoplastic neurological syndrome is an immune-mediated phenomenon where antibodies from tumor cells are produced against neuronal proteins. Amphiphysin antibody is an onconeural antibody linked to the diagnosis of breast cancer and small-cell lung cancer. It is uncommon and typically associated with stiff-person syndrome, of which 90% of patients are eventually diagnosed with breast cancer. CASE PRESENTATION: We present a case of a 47-year-old Caucasian woman with metastatic hormone receptor-positive breast cancer who developed bilateral facial nerve palsy while on treatment with nab-paclitaxel. The patient was found to have anti-amphiphysin antibody in the serum and cerebrospinal fluid. She was treated with methylprednisolone and intravenous immunoglobulin, which resulted in partial improvement in her facial nerve palsy. CONCLUSIONS: This case highlights a rare presentation of bilateral facial nerve palsy that likely related to paraneoplastic syndrome associated with the presence of anti-amphiphysin antibody. BioMed Central 2021-03-26 /pmc/articles/PMC7995578/ /pubmed/33766120 http://dx.doi.org/10.1186/s13256-021-02727-3 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Kwatra, Vineet Charakidis, Michail Karanth, Narayan V. Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report |
title | Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report |
title_full | Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report |
title_fullStr | Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report |
title_full_unstemmed | Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report |
title_short | Bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report |
title_sort | bilateral facial nerve palsy associated with amphiphysin antibody in metastatic breast cancer: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995578/ https://www.ncbi.nlm.nih.gov/pubmed/33766120 http://dx.doi.org/10.1186/s13256-021-02727-3 |
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