Fibroblasts in cancer dormancy: foe or friend?

Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining t...

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Autores principales: Dai, Li, Li, Mao, Zhang, Wei-long, Tang, Ya-Jie, Tang, Ya-ling, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995785/
https://www.ncbi.nlm.nih.gov/pubmed/33771156
http://dx.doi.org/10.1186/s12935-021-01883-2
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author Dai, Li
Li, Mao
Zhang, Wei-long
Tang, Ya-Jie
Tang, Ya-ling
Liang, Xin-hua
author_facet Dai, Li
Li, Mao
Zhang, Wei-long
Tang, Ya-Jie
Tang, Ya-ling
Liang, Xin-hua
author_sort Dai, Li
collection PubMed
description Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining the ultimate fate of tumor cells. This review recapitulates the pleiotropic roles of fibroblasts which are divided into normal, senescent, cancer-associated fibroblasts (CAFs) and circulation CAFs in tumor dormancy, relapse, metastasis and resistance to therapy to help the treatment of cancer metastasis.
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spelling pubmed-79957852021-03-30 Fibroblasts in cancer dormancy: foe or friend? Dai, Li Li, Mao Zhang, Wei-long Tang, Ya-Jie Tang, Ya-ling Liang, Xin-hua Cancer Cell Int Review Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which represent a predominant cell type in tumor microenvironment, play a pivotal role in determining the ultimate fate of tumor cells. This review recapitulates the pleiotropic roles of fibroblasts which are divided into normal, senescent, cancer-associated fibroblasts (CAFs) and circulation CAFs in tumor dormancy, relapse, metastasis and resistance to therapy to help the treatment of cancer metastasis. BioMed Central 2021-03-26 /pmc/articles/PMC7995785/ /pubmed/33771156 http://dx.doi.org/10.1186/s12935-021-01883-2 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Dai, Li
Li, Mao
Zhang, Wei-long
Tang, Ya-Jie
Tang, Ya-ling
Liang, Xin-hua
Fibroblasts in cancer dormancy: foe or friend?
title Fibroblasts in cancer dormancy: foe or friend?
title_full Fibroblasts in cancer dormancy: foe or friend?
title_fullStr Fibroblasts in cancer dormancy: foe or friend?
title_full_unstemmed Fibroblasts in cancer dormancy: foe or friend?
title_short Fibroblasts in cancer dormancy: foe or friend?
title_sort fibroblasts in cancer dormancy: foe or friend?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995785/
https://www.ncbi.nlm.nih.gov/pubmed/33771156
http://dx.doi.org/10.1186/s12935-021-01883-2
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