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Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway

Mechanical stimulation induces bone growth and remodeling by the secondary messenger, cyclic guanosine 3’, 5’-monophosphate (cGMP), in osteoblasts. However, the role of cGMP in the regulation of estrogen biosynthesis, whose deficiency is a major cause of osteoporosis, remains unclear. Here, we found...

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Detalles Bibliográficos
Autores principales:	Wisanwattana, Wisanee, Wongkrajang, Kanjana, Cao, Dong-yi, Shi, Xiao-ke, Zhang, Zhong-hui, Zhou, Zong-yuan, Li, Fu, Mei, Qing-gang, Wang, Chun, Suksamrarn, Apichart, Zhang, Guo-lin, Wang, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995890/ https://www.ncbi.nlm.nih.gov/pubmed/33776932 http://dx.doi.org/10.3389/fendo.2021.636784

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