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Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management
Since alterations of the gut microbiota have been shown to play a major role in obesity, probiotics have attracted attention. Our aim was to identify probiotic candidates for the management of obesity using a combination of in vitro and in vivo approaches. We evaluated in vitro the ability of 23 str...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995962/ https://www.ncbi.nlm.nih.gov/pubmed/33668212 http://dx.doi.org/10.3390/nu13030713 |
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author | Alard, Jeanne Cudennec, Benoit Boutillier, Denise Peucelle, Véronique Descat, Amandine Decoin, Raphaël Kuylle, Sarah Jablaoui, Amin Rhimi, Moez Wolowczuk, Isabelle Pot, Bruno Tailleux, Anne Maguin, Emmanuelle Holowacz, Sophie Grangette, Corinne |
author_facet | Alard, Jeanne Cudennec, Benoit Boutillier, Denise Peucelle, Véronique Descat, Amandine Decoin, Raphaël Kuylle, Sarah Jablaoui, Amin Rhimi, Moez Wolowczuk, Isabelle Pot, Bruno Tailleux, Anne Maguin, Emmanuelle Holowacz, Sophie Grangette, Corinne |
author_sort | Alard, Jeanne |
collection | PubMed |
description | Since alterations of the gut microbiota have been shown to play a major role in obesity, probiotics have attracted attention. Our aim was to identify probiotic candidates for the management of obesity using a combination of in vitro and in vivo approaches. We evaluated in vitro the ability of 23 strains to limit lipid accumulation in adipocytes and to enhance the secretion of satiety-promoting gut peptide in enteroendocrine cells. Following the in vitro screening, selected strains were further investigated in vivo, single, or as mixtures, using a murine model of diet-induced obesity. Strain Bifidobacterium longum PI10 administrated alone and the mixture of B. animalis subsp. lactis LA804 and Lactobacillus gasseri LA806 limited body weight gain and reduced obesity-associated metabolic dysfunction and inflammation. These protective effects were associated with changes in the hypothalamic gene expression of leptin and leptin receptor as well as with changes in the composition of gut microbiota and the profile of bile acids. This study provides crucial clues to identify new potential probiotics as effective therapeutic approaches in the management of obesity, while also providing some insights into their mechanisms of action. |
format | Online Article Text |
id | pubmed-7995962 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79959622021-03-27 Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management Alard, Jeanne Cudennec, Benoit Boutillier, Denise Peucelle, Véronique Descat, Amandine Decoin, Raphaël Kuylle, Sarah Jablaoui, Amin Rhimi, Moez Wolowczuk, Isabelle Pot, Bruno Tailleux, Anne Maguin, Emmanuelle Holowacz, Sophie Grangette, Corinne Nutrients Article Since alterations of the gut microbiota have been shown to play a major role in obesity, probiotics have attracted attention. Our aim was to identify probiotic candidates for the management of obesity using a combination of in vitro and in vivo approaches. We evaluated in vitro the ability of 23 strains to limit lipid accumulation in adipocytes and to enhance the secretion of satiety-promoting gut peptide in enteroendocrine cells. Following the in vitro screening, selected strains were further investigated in vivo, single, or as mixtures, using a murine model of diet-induced obesity. Strain Bifidobacterium longum PI10 administrated alone and the mixture of B. animalis subsp. lactis LA804 and Lactobacillus gasseri LA806 limited body weight gain and reduced obesity-associated metabolic dysfunction and inflammation. These protective effects were associated with changes in the hypothalamic gene expression of leptin and leptin receptor as well as with changes in the composition of gut microbiota and the profile of bile acids. This study provides crucial clues to identify new potential probiotics as effective therapeutic approaches in the management of obesity, while also providing some insights into their mechanisms of action. MDPI 2021-02-24 /pmc/articles/PMC7995962/ /pubmed/33668212 http://dx.doi.org/10.3390/nu13030713 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Alard, Jeanne Cudennec, Benoit Boutillier, Denise Peucelle, Véronique Descat, Amandine Decoin, Raphaël Kuylle, Sarah Jablaoui, Amin Rhimi, Moez Wolowczuk, Isabelle Pot, Bruno Tailleux, Anne Maguin, Emmanuelle Holowacz, Sophie Grangette, Corinne Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management |
title | Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management |
title_full | Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management |
title_fullStr | Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management |
title_full_unstemmed | Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management |
title_short | Multiple Selection Criteria for Probiotic Strains with High Potential for Obesity Management |
title_sort | multiple selection criteria for probiotic strains with high potential for obesity management |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995962/ https://www.ncbi.nlm.nih.gov/pubmed/33668212 http://dx.doi.org/10.3390/nu13030713 |
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