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Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI

Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women...

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Autores principales: Khandelwal, Shweta, Kondal, Dimple, Chaudhry, Monica, Patil, Kamal, Swamy, Mallaiah Kenchaveeraiah, Pujeri, Gangubai, Mane, Swati Babu, Kudachi, Yashaswi, Gupta, Ruby, Ramakrishnan, Usha, Stein, Aryeh D., Prabhakaran, Dorairaj, Tandon, Nikhil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996222/
https://www.ncbi.nlm.nih.gov/pubmed/33668849
http://dx.doi.org/10.3390/nu13030730
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author Khandelwal, Shweta
Kondal, Dimple
Chaudhry, Monica
Patil, Kamal
Swamy, Mallaiah Kenchaveeraiah
Pujeri, Gangubai
Mane, Swati Babu
Kudachi, Yashaswi
Gupta, Ruby
Ramakrishnan, Usha
Stein, Aryeh D.
Prabhakaran, Dorairaj
Tandon, Nikhil
author_facet Khandelwal, Shweta
Kondal, Dimple
Chaudhry, Monica
Patil, Kamal
Swamy, Mallaiah Kenchaveeraiah
Pujeri, Gangubai
Mane, Swati Babu
Kudachi, Yashaswi
Gupta, Ruby
Ramakrishnan, Usha
Stein, Aryeh D.
Prabhakaran, Dorairaj
Tandon, Nikhil
author_sort Khandelwal, Shweta
collection PubMed
description Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; n = 478 and placebo; n = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, p = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, p = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, p = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, p = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference.
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spelling pubmed-79962222021-03-27 Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI Khandelwal, Shweta Kondal, Dimple Chaudhry, Monica Patil, Kamal Swamy, Mallaiah Kenchaveeraiah Pujeri, Gangubai Mane, Swati Babu Kudachi, Yashaswi Gupta, Ruby Ramakrishnan, Usha Stein, Aryeh D. Prabhakaran, Dorairaj Tandon, Nikhil Nutrients Article Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; n = 478 and placebo; n = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, p = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, p = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, p = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, p = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference. MDPI 2021-02-25 /pmc/articles/PMC7996222/ /pubmed/33668849 http://dx.doi.org/10.3390/nu13030730 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Khandelwal, Shweta
Kondal, Dimple
Chaudhry, Monica
Patil, Kamal
Swamy, Mallaiah Kenchaveeraiah
Pujeri, Gangubai
Mane, Swati Babu
Kudachi, Yashaswi
Gupta, Ruby
Ramakrishnan, Usha
Stein, Aryeh D.
Prabhakaran, Dorairaj
Tandon, Nikhil
Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
title Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
title_full Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
title_fullStr Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
title_full_unstemmed Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
title_short Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI
title_sort prenatal maternal docosahexaenoic acid (dha) supplementation and newborn anthropometry in india: findings from dhani
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996222/
https://www.ncbi.nlm.nih.gov/pubmed/33668849
http://dx.doi.org/10.3390/nu13030730
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