A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes

In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging...

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Autores principales: Khvorykh, Gennady, Khrunin, Andrey, Filippenkov, Ivan, Stavchansky, Vasily, Dergunova, Lyudmila, Limborska, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996278/
https://www.ncbi.nlm.nih.gov/pubmed/33668793
http://dx.doi.org/10.3390/genes12030328
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author Khvorykh, Gennady
Khrunin, Andrey
Filippenkov, Ivan
Stavchansky, Vasily
Dergunova, Lyudmila
Limborska, Svetlana
author_facet Khvorykh, Gennady
Khrunin, Andrey
Filippenkov, Ivan
Stavchansky, Vasily
Dergunova, Lyudmila
Limborska, Svetlana
author_sort Khvorykh, Gennady
collection PubMed
description In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on their expression as well.
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spelling pubmed-79962782021-03-27 A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes Khvorykh, Gennady Khrunin, Andrey Filippenkov, Ivan Stavchansky, Vasily Dergunova, Lyudmila Limborska, Svetlana Genes (Basel) Article In this paper we propose a workflow for studying the genetic architecture of ischemic stroke outcomes. It develops further the candidate gene approach. The workflow is based on the animal model of brain ischemia, comparative genomics, human genomic variations, and algorithms of selection of tagging single nucleotide polymorphisms (tagSNPs) in genes which expression was changed after ischemic stroke. The workflow starts from a set of rat genes that changed their expression in response to brain ischemia and results in a set of tagSNPs, which represent other SNPs in the human genes analyzed and influenced on their expression as well. MDPI 2021-02-25 /pmc/articles/PMC7996278/ /pubmed/33668793 http://dx.doi.org/10.3390/genes12030328 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Khvorykh, Gennady
Khrunin, Andrey
Filippenkov, Ivan
Stavchansky, Vasily
Dergunova, Lyudmila
Limborska, Svetlana
A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes
title A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes
title_full A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes
title_fullStr A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes
title_full_unstemmed A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes
title_short A Workflow for Selection of Single Nucleotide Polymorphic Markers for Studying of Genetics of Ischemic Stroke Outcomes
title_sort workflow for selection of single nucleotide polymorphic markers for studying of genetics of ischemic stroke outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996278/
https://www.ncbi.nlm.nih.gov/pubmed/33668793
http://dx.doi.org/10.3390/genes12030328
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