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Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer

Photodynamic therapy (PDT) is an alternative modality to conventional cancer treatment, whereby a specific wavelength of light is applied to a targeted tumor, which has either a photosensitizer or photochemotherapeutic agent localized within it. This light activates the photosensitizer in the presen...

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Autores principales: Montaseri, Hanieh, Kruger, Cherie Ann, Abrahamse, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996317/
https://www.ncbi.nlm.nih.gov/pubmed/33668307
http://dx.doi.org/10.3390/pharmaceutics13030296
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author Montaseri, Hanieh
Kruger, Cherie Ann
Abrahamse, Heidi
author_facet Montaseri, Hanieh
Kruger, Cherie Ann
Abrahamse, Heidi
author_sort Montaseri, Hanieh
collection PubMed
description Photodynamic therapy (PDT) is an alternative modality to conventional cancer treatment, whereby a specific wavelength of light is applied to a targeted tumor, which has either a photosensitizer or photochemotherapeutic agent localized within it. This light activates the photosensitizer in the presence of molecular oxygen to produce phototoxic species, which in turn obliterate cancer cells. The incidence rate of breast cancer (BC) is regularly growing among women, which are currently being treated with methods, such as chemotherapy, radiotherapy, and surgery. These conventional treatment methods are invasive and often produce unwanted side effects, whereas PDT is more specific and localized method of cancer treatment. The utilization of nanoparticles in PDT has shown great advantages compared to free photosensitizers in terms of solubility, early degradation, and biodistribution, as well as far more effective intercellular penetration and uptake in targeted cancer cells. This review gives an overview of the use of inorganic nanoparticles (NPs), including: gold, magnetic, carbon-based, ceramic, and up-conversion NPs, as well as quantum dots in PDT over the last 10 years (2009 to 2019), with a particular focus on the active targeting strategies for the PDT treatment of BC.
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spelling pubmed-79963172021-03-27 Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer Montaseri, Hanieh Kruger, Cherie Ann Abrahamse, Heidi Pharmaceutics Review Photodynamic therapy (PDT) is an alternative modality to conventional cancer treatment, whereby a specific wavelength of light is applied to a targeted tumor, which has either a photosensitizer or photochemotherapeutic agent localized within it. This light activates the photosensitizer in the presence of molecular oxygen to produce phototoxic species, which in turn obliterate cancer cells. The incidence rate of breast cancer (BC) is regularly growing among women, which are currently being treated with methods, such as chemotherapy, radiotherapy, and surgery. These conventional treatment methods are invasive and often produce unwanted side effects, whereas PDT is more specific and localized method of cancer treatment. The utilization of nanoparticles in PDT has shown great advantages compared to free photosensitizers in terms of solubility, early degradation, and biodistribution, as well as far more effective intercellular penetration and uptake in targeted cancer cells. This review gives an overview of the use of inorganic nanoparticles (NPs), including: gold, magnetic, carbon-based, ceramic, and up-conversion NPs, as well as quantum dots in PDT over the last 10 years (2009 to 2019), with a particular focus on the active targeting strategies for the PDT treatment of BC. MDPI 2021-02-24 /pmc/articles/PMC7996317/ /pubmed/33668307 http://dx.doi.org/10.3390/pharmaceutics13030296 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Montaseri, Hanieh
Kruger, Cherie Ann
Abrahamse, Heidi
Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer
title Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer
title_full Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer
title_fullStr Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer
title_full_unstemmed Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer
title_short Inorganic Nanoparticles Applied for Active Targeted Photodynamic Therapy of Breast Cancer
title_sort inorganic nanoparticles applied for active targeted photodynamic therapy of breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996317/
https://www.ncbi.nlm.nih.gov/pubmed/33668307
http://dx.doi.org/10.3390/pharmaceutics13030296
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