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Cost of Illness in Young Children: A Prospective Birth Cohort Study

Childhood illness is extremely common and imposes a considerable economic burden on society. We aimed to quantify the overall economic burden of childhood illness in the first three years of life and the impact of environmental risk factors. The study is based on the prospective, clinical mother–chi...

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Autores principales: Nørgaard, Sarah Kristine, Vissing, Nadja Hawwa, Chawes, Bo Lund, Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996350/
https://www.ncbi.nlm.nih.gov/pubmed/33668336
http://dx.doi.org/10.3390/children8030173
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author Nørgaard, Sarah Kristine
Vissing, Nadja Hawwa
Chawes, Bo Lund
Stokholm, Jakob
Bønnelykke, Klaus
Bisgaard, Hans
author_facet Nørgaard, Sarah Kristine
Vissing, Nadja Hawwa
Chawes, Bo Lund
Stokholm, Jakob
Bønnelykke, Klaus
Bisgaard, Hans
author_sort Nørgaard, Sarah Kristine
collection PubMed
description Childhood illness is extremely common and imposes a considerable economic burden on society. We aimed to quantify the overall economic burden of childhood illness in the first three years of life and the impact of environmental risk factors. The study is based on the prospective, clinical mother–child cohort Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010) of 700 children with embedded randomized trials of fish-oil and vitamin D supplementations during pregnancy. First, descriptive analyses were performed on the total costs of illness, defined as both the direct costs (hospitalizations, outpatient visits, visit to the practitioner) and the indirect costs (lost earnings) collected from the Danish National Health Registries. Thereafter, linear regression analyses on log-transformed costs were used to investigate environmental determinants of the costs of illness. The median standardized total cost of illness at age 0–3 years among the 559 children eligible for analyses was EUR 14,061 (IQR 9751–19,662). The exposures associated with reduced costs were fish-oil supplementation during pregnancy (adjusted geometric mean ratio (GMR) 0.89 (0.80; 0.98), p = 0.02), gestational age in weeks (aGMR = 0.93 (0.91; 0.96), p < 0.0001), and birth weight per 100 g (aGMR 0.98 (0.97; 0.99), p = 0.0003), while cesarean delivery was associated with higher costs (aGMR = 1.30 (1.15; 1.47), p < 0.0001). In conclusion, common childhood illnesses are associated with significant health-related costs, which can potentially be reduced by targeting perinatal risk factors, including maternal diet during pregnancy, cesarean delivery, preterm birth and low birth weight.
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spelling pubmed-79963502021-03-27 Cost of Illness in Young Children: A Prospective Birth Cohort Study Nørgaard, Sarah Kristine Vissing, Nadja Hawwa Chawes, Bo Lund Stokholm, Jakob Bønnelykke, Klaus Bisgaard, Hans Children (Basel) Article Childhood illness is extremely common and imposes a considerable economic burden on society. We aimed to quantify the overall economic burden of childhood illness in the first three years of life and the impact of environmental risk factors. The study is based on the prospective, clinical mother–child cohort Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010) of 700 children with embedded randomized trials of fish-oil and vitamin D supplementations during pregnancy. First, descriptive analyses were performed on the total costs of illness, defined as both the direct costs (hospitalizations, outpatient visits, visit to the practitioner) and the indirect costs (lost earnings) collected from the Danish National Health Registries. Thereafter, linear regression analyses on log-transformed costs were used to investigate environmental determinants of the costs of illness. The median standardized total cost of illness at age 0–3 years among the 559 children eligible for analyses was EUR 14,061 (IQR 9751–19,662). The exposures associated with reduced costs were fish-oil supplementation during pregnancy (adjusted geometric mean ratio (GMR) 0.89 (0.80; 0.98), p = 0.02), gestational age in weeks (aGMR = 0.93 (0.91; 0.96), p < 0.0001), and birth weight per 100 g (aGMR 0.98 (0.97; 0.99), p = 0.0003), while cesarean delivery was associated with higher costs (aGMR = 1.30 (1.15; 1.47), p < 0.0001). In conclusion, common childhood illnesses are associated with significant health-related costs, which can potentially be reduced by targeting perinatal risk factors, including maternal diet during pregnancy, cesarean delivery, preterm birth and low birth weight. MDPI 2021-02-24 /pmc/articles/PMC7996350/ /pubmed/33668336 http://dx.doi.org/10.3390/children8030173 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Nørgaard, Sarah Kristine
Vissing, Nadja Hawwa
Chawes, Bo Lund
Stokholm, Jakob
Bønnelykke, Klaus
Bisgaard, Hans
Cost of Illness in Young Children: A Prospective Birth Cohort Study
title Cost of Illness in Young Children: A Prospective Birth Cohort Study
title_full Cost of Illness in Young Children: A Prospective Birth Cohort Study
title_fullStr Cost of Illness in Young Children: A Prospective Birth Cohort Study
title_full_unstemmed Cost of Illness in Young Children: A Prospective Birth Cohort Study
title_short Cost of Illness in Young Children: A Prospective Birth Cohort Study
title_sort cost of illness in young children: a prospective birth cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996350/
https://www.ncbi.nlm.nih.gov/pubmed/33668336
http://dx.doi.org/10.3390/children8030173
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