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RNA Helicase A Regulates the Replication of RNA Viruses

The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell. RHA is also hijacked by a variety of RNA viruses to facilitate virus rep...

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Detalles Bibliográficos
Autores principales: Shi, Rui-Zhu, Pan, Yuan-Qing, Xing, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996507/
https://www.ncbi.nlm.nih.gov/pubmed/33668948
http://dx.doi.org/10.3390/v13030361
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author Shi, Rui-Zhu
Pan, Yuan-Qing
Xing, Li
author_facet Shi, Rui-Zhu
Pan, Yuan-Qing
Xing, Li
author_sort Shi, Rui-Zhu
collection PubMed
description The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell. RHA is also hijacked by a variety of RNA viruses to facilitate virus replication. Herein, this review will provide an overview of the role of RHA in the replication of RNA viruses.
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spelling pubmed-79965072021-03-27 RNA Helicase A Regulates the Replication of RNA Viruses Shi, Rui-Zhu Pan, Yuan-Qing Xing, Li Viruses Review The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell. RHA is also hijacked by a variety of RNA viruses to facilitate virus replication. Herein, this review will provide an overview of the role of RHA in the replication of RNA viruses. MDPI 2021-02-25 /pmc/articles/PMC7996507/ /pubmed/33668948 http://dx.doi.org/10.3390/v13030361 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Shi, Rui-Zhu
Pan, Yuan-Qing
Xing, Li
RNA Helicase A Regulates the Replication of RNA Viruses
title RNA Helicase A Regulates the Replication of RNA Viruses
title_full RNA Helicase A Regulates the Replication of RNA Viruses
title_fullStr RNA Helicase A Regulates the Replication of RNA Viruses
title_full_unstemmed RNA Helicase A Regulates the Replication of RNA Viruses
title_short RNA Helicase A Regulates the Replication of RNA Viruses
title_sort rna helicase a regulates the replication of rna viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996507/
https://www.ncbi.nlm.nih.gov/pubmed/33668948
http://dx.doi.org/10.3390/v13030361
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