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Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy
Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto double) significantly upto 2030. The poor c...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996600/ https://www.ncbi.nlm.nih.gov/pubmed/33669097 http://dx.doi.org/10.3390/biom11030350 |
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author | Arya, Ashwani Chahal, Rubal Rao, Rekha Rahman, Md. Habibur Kaushik, Deepak Akhtar, Muhammad Furqan Saleem, Ammara Khalifa, Shaden M. A. El-Seedi, Hesham R. Kamel, Mohamed Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Mittal, Vineet |
author_facet | Arya, Ashwani Chahal, Rubal Rao, Rekha Rahman, Md. Habibur Kaushik, Deepak Akhtar, Muhammad Furqan Saleem, Ammara Khalifa, Shaden M. A. El-Seedi, Hesham R. Kamel, Mohamed Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Mittal, Vineet |
author_sort | Arya, Ashwani |
collection | PubMed |
description | Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto double) significantly upto 2030. The poor cholinergic transmission at the synapse is considered to be one of the main reasons behind the progression and occurrence of this disorder. Natural inhibitors of acetylcholine (ACh) such as galanthamine and rivastigmine are used commercially in the treatmentof AD. The biomolecules such assesquiterpenes, possess a great structural diversity and are responsible for a plethora of pharmacological properties. The potential of various sesquiterpenes as anticholinesterase has been reviewed in this article. For this purpose, the various databases, mainly PubMed, Scopus, and Web of Science were investigatedwith different keywords such as “sesquiterpenes+acetylcholinesterase” and “sesquiterpenes+cholinesterase+inhibitors” in the surveyed time frame (2010–2020). A vast literature was evident in the last decade, which affirms the potential of various sesquiterpenes in the improvement of cholinergic transmission by inhibiting the AChE. After data analysis, it was found that 12 compounds out of a total of 58 sesquiterpenes were reported to possess IC(50) < 9 μM and can be considered as potential candidates for the improvement of learning and memory. Sesquiterpene is an important category of terpenoids, found to possess a large spectrum of biological activities. The outcome of the review clearly states that sesquiterpenes (such as amberboin, lipidiol, etc.) from herbs could offer fresh, functional compounds for possible prevention and treatment of AD. |
format | Online Article Text |
id | pubmed-7996600 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79966002021-03-27 Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy Arya, Ashwani Chahal, Rubal Rao, Rekha Rahman, Md. Habibur Kaushik, Deepak Akhtar, Muhammad Furqan Saleem, Ammara Khalifa, Shaden M. A. El-Seedi, Hesham R. Kamel, Mohamed Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Mittal, Vineet Biomolecules Review Alzheimer’s disease (AD) is a gradually growing irreversible illness of the brain that almost affects every fifth person (aged > 80 years) in the world. World Health Organization (WHO) also revealed that the prevalence of this disease will enhance (upto double) significantly upto 2030. The poor cholinergic transmission at the synapse is considered to be one of the main reasons behind the progression and occurrence of this disorder. Natural inhibitors of acetylcholine (ACh) such as galanthamine and rivastigmine are used commercially in the treatmentof AD. The biomolecules such assesquiterpenes, possess a great structural diversity and are responsible for a plethora of pharmacological properties. The potential of various sesquiterpenes as anticholinesterase has been reviewed in this article. For this purpose, the various databases, mainly PubMed, Scopus, and Web of Science were investigatedwith different keywords such as “sesquiterpenes+acetylcholinesterase” and “sesquiterpenes+cholinesterase+inhibitors” in the surveyed time frame (2010–2020). A vast literature was evident in the last decade, which affirms the potential of various sesquiterpenes in the improvement of cholinergic transmission by inhibiting the AChE. After data analysis, it was found that 12 compounds out of a total of 58 sesquiterpenes were reported to possess IC(50) < 9 μM and can be considered as potential candidates for the improvement of learning and memory. Sesquiterpene is an important category of terpenoids, found to possess a large spectrum of biological activities. The outcome of the review clearly states that sesquiterpenes (such as amberboin, lipidiol, etc.) from herbs could offer fresh, functional compounds for possible prevention and treatment of AD. MDPI 2021-02-25 /pmc/articles/PMC7996600/ /pubmed/33669097 http://dx.doi.org/10.3390/biom11030350 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Arya, Ashwani Chahal, Rubal Rao, Rekha Rahman, Md. Habibur Kaushik, Deepak Akhtar, Muhammad Furqan Saleem, Ammara Khalifa, Shaden M. A. El-Seedi, Hesham R. Kamel, Mohamed Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Mittal, Vineet Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy |
title | Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy |
title_full | Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy |
title_fullStr | Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy |
title_full_unstemmed | Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy |
title_short | Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy |
title_sort | acetylcholinesterase inhibitory potential of various sesquiterpene analogues for alzheimer’s disease therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996600/ https://www.ncbi.nlm.nih.gov/pubmed/33669097 http://dx.doi.org/10.3390/biom11030350 |
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