When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report

Immune-related hepatitis (IRH) is a frequent but poorly understood immune-related adverse event and its frequency increases since the use of combination therapy in several cancer types. Therefore, there is an urgent need to develop adapted guidelines to manage IRH. In the present letter, based on Zi...

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Autores principales: Gauci, Marie-Léa, Baroudjian, Barouyr, Lebbe, Celeste, Roux, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996650/
https://www.ncbi.nlm.nih.gov/pubmed/33771893
http://dx.doi.org/10.1136/jitc-2021-002337
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author Gauci, Marie-Léa
Baroudjian, Barouyr
Lebbe, Celeste
Roux, Olivier
author_facet Gauci, Marie-Léa
Baroudjian, Barouyr
Lebbe, Celeste
Roux, Olivier
author_sort Gauci, Marie-Léa
collection PubMed
description Immune-related hepatitis (IRH) is a frequent but poorly understood immune-related adverse event and its frequency increases since the use of combination therapy in several cancer types. Therefore, there is an urgent need to develop adapted guidelines to manage IRH. In the present letter, based on Ziogas et al report entitled ‘When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report’, several points are discussed: assessment of IRH severity and liver biopsy indication, immune-related cholangitis as a differential diagnosis for some IRH presentation, the need of steroids for IRH management or the indication for second line immunosuppressive treatment and finally, the possibility of immunotherapy resumption.
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spelling pubmed-79966502021-04-16 When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report Gauci, Marie-Léa Baroudjian, Barouyr Lebbe, Celeste Roux, Olivier J Immunother Cancer Commentary Immune-related hepatitis (IRH) is a frequent but poorly understood immune-related adverse event and its frequency increases since the use of combination therapy in several cancer types. Therefore, there is an urgent need to develop adapted guidelines to manage IRH. In the present letter, based on Ziogas et al report entitled ‘When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report’, several points are discussed: assessment of IRH severity and liver biopsy indication, immune-related cholangitis as a differential diagnosis for some IRH presentation, the need of steroids for IRH management or the indication for second line immunosuppressive treatment and finally, the possibility of immunotherapy resumption. BMJ Publishing Group 2021-03-25 /pmc/articles/PMC7996650/ /pubmed/33771893 http://dx.doi.org/10.1136/jitc-2021-002337 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Commentary
Gauci, Marie-Léa
Baroudjian, Barouyr
Lebbe, Celeste
Roux, Olivier
When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report
title When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report
title_full When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report
title_fullStr When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report
title_full_unstemmed When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report
title_short When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report
title_sort when steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996650/
https://www.ncbi.nlm.nih.gov/pubmed/33771893
http://dx.doi.org/10.1136/jitc-2021-002337
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