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The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mas...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996723/ https://www.ncbi.nlm.nih.gov/pubmed/33652910 http://dx.doi.org/10.3390/nu13030764 |
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author | Roberts, Justin D. Willmott, Ashley G. B. Beasley, Liam Boal, Mariette Davies, Rory Martin, Laurence Chichger, Havovi Gautam, Lata Del Coso, Juan |
author_facet | Roberts, Justin D. Willmott, Ashley G. B. Beasley, Liam Boal, Mariette Davies, Rory Martin, Laurence Chichger, Havovi Gautam, Lata Del Coso, Juan |
author_sort | Roberts, Justin D. |
collection | PubMed |
description | This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mass: 77.5 ± 10.5 kg; body mass index: 27.4 ± 3.0 kg·m(2); peak oxygen uptake ([Formula: see text] O(2peak)): 30.2 ± 5.8 mL·kg(−1)·min(−1)) were randomly assigned, in a double-blinded manner, either: dGTE (400 mg·d(−1) (−)-epigallocatechin−3-gallate (EGCG), n = 9); a novel dGTE+ (400 mg·d(−1) EGCG, quercetin (50 mg·d(−1)) and α-lipoic acid (LA, 150 mg·d(−1)), n = 9); or placebo (PL, n = 9) for 8 weeks, whilst maintaining standardised, aerobic exercise. Fat oxidation (‘FAT(MAX)’ and steady state exercise protocols), body composition, cardio-metabolic and blood measures (serum glucose, insulin, leptin, adiponectin, glycerol, free fatty acids, total cholesterol, high [HDL-c] and low-density lipoprotein cholesterol [LDL-c], triglycerides, liver enzymes and bilirubin) were assessed at baseline, week 4 and 8. Following 8 weeks of dGTE+, maximal fat oxidation (MFO) significantly improved from 154.4 ± 20.6 to 224.6 ± 23.2 mg·min(−1) (p = 0.009), along with a 22.5% increase in the exercise intensity at which fat oxidation was deemed negligible (FAT(MIN); 67.6 ± 3.6% [Formula: see text] O(2peak), p = 0.003). Steady state exercise substrate utilisation also improved for dGTE+ only, with respiratory exchange ratio reducing from 0.94 ± 0.01 at week 4, to 0.89 ± 0.01 at week 8 (p = 0.004). This corresponded with a significant increase in the contribution of fat to energy expenditure for dGTE+ from 21.0 ± 4.1% at week 4, to 34.6 ± 4.7% at week 8 (p = 0.006). LDL-c was also lower (normalised fold change of −0.09 ± 0.06) for dGTE+ by week 8 (p = 0.038). No other significant effects were found in any group. Eight weeks of dGTE+ improved MFO and substrate utilisation during exercise, and lowered LDL-c. However, body composition and cardio-metabolic markers in healthy, overweight individuals who maintained regular physical activity were largely unaffected by dGTE. |
format | Online Article Text |
id | pubmed-7996723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79967232021-03-27 The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals Roberts, Justin D. Willmott, Ashley G. B. Beasley, Liam Boal, Mariette Davies, Rory Martin, Laurence Chichger, Havovi Gautam, Lata Del Coso, Juan Nutrients Article This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mass: 77.5 ± 10.5 kg; body mass index: 27.4 ± 3.0 kg·m(2); peak oxygen uptake ([Formula: see text] O(2peak)): 30.2 ± 5.8 mL·kg(−1)·min(−1)) were randomly assigned, in a double-blinded manner, either: dGTE (400 mg·d(−1) (−)-epigallocatechin−3-gallate (EGCG), n = 9); a novel dGTE+ (400 mg·d(−1) EGCG, quercetin (50 mg·d(−1)) and α-lipoic acid (LA, 150 mg·d(−1)), n = 9); or placebo (PL, n = 9) for 8 weeks, whilst maintaining standardised, aerobic exercise. Fat oxidation (‘FAT(MAX)’ and steady state exercise protocols), body composition, cardio-metabolic and blood measures (serum glucose, insulin, leptin, adiponectin, glycerol, free fatty acids, total cholesterol, high [HDL-c] and low-density lipoprotein cholesterol [LDL-c], triglycerides, liver enzymes and bilirubin) were assessed at baseline, week 4 and 8. Following 8 weeks of dGTE+, maximal fat oxidation (MFO) significantly improved from 154.4 ± 20.6 to 224.6 ± 23.2 mg·min(−1) (p = 0.009), along with a 22.5% increase in the exercise intensity at which fat oxidation was deemed negligible (FAT(MIN); 67.6 ± 3.6% [Formula: see text] O(2peak), p = 0.003). Steady state exercise substrate utilisation also improved for dGTE+ only, with respiratory exchange ratio reducing from 0.94 ± 0.01 at week 4, to 0.89 ± 0.01 at week 8 (p = 0.004). This corresponded with a significant increase in the contribution of fat to energy expenditure for dGTE+ from 21.0 ± 4.1% at week 4, to 34.6 ± 4.7% at week 8 (p = 0.006). LDL-c was also lower (normalised fold change of −0.09 ± 0.06) for dGTE+ by week 8 (p = 0.038). No other significant effects were found in any group. Eight weeks of dGTE+ improved MFO and substrate utilisation during exercise, and lowered LDL-c. However, body composition and cardio-metabolic markers in healthy, overweight individuals who maintained regular physical activity were largely unaffected by dGTE. MDPI 2021-02-26 /pmc/articles/PMC7996723/ /pubmed/33652910 http://dx.doi.org/10.3390/nu13030764 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Roberts, Justin D. Willmott, Ashley G. B. Beasley, Liam Boal, Mariette Davies, Rory Martin, Laurence Chichger, Havovi Gautam, Lata Del Coso, Juan The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals |
title | The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals |
title_full | The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals |
title_fullStr | The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals |
title_full_unstemmed | The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals |
title_short | The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals |
title_sort | impact of decaffeinated green tea extract on fat oxidation, body composition and cardio-metabolic health in overweight, recreationally active individuals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996723/ https://www.ncbi.nlm.nih.gov/pubmed/33652910 http://dx.doi.org/10.3390/nu13030764 |
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