Cargando…

The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mas...

Descripción completa

Detalles Bibliográficos
Autores principales: Roberts, Justin D., Willmott, Ashley G. B., Beasley, Liam, Boal, Mariette, Davies, Rory, Martin, Laurence, Chichger, Havovi, Gautam, Lata, Del Coso, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996723/
https://www.ncbi.nlm.nih.gov/pubmed/33652910
http://dx.doi.org/10.3390/nu13030764
_version_ 1783670164856766464
author Roberts, Justin D.
Willmott, Ashley G. B.
Beasley, Liam
Boal, Mariette
Davies, Rory
Martin, Laurence
Chichger, Havovi
Gautam, Lata
Del Coso, Juan
author_facet Roberts, Justin D.
Willmott, Ashley G. B.
Beasley, Liam
Boal, Mariette
Davies, Rory
Martin, Laurence
Chichger, Havovi
Gautam, Lata
Del Coso, Juan
author_sort Roberts, Justin D.
collection PubMed
description This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mass: 77.5 ± 10.5 kg; body mass index: 27.4 ± 3.0 kg·m(2); peak oxygen uptake ([Formula: see text] O(2peak)): 30.2 ± 5.8 mL·kg(−1)·min(−1)) were randomly assigned, in a double-blinded manner, either: dGTE (400 mg·d(−1) (−)-epigallocatechin−3-gallate (EGCG), n = 9); a novel dGTE+ (400 mg·d(−1) EGCG, quercetin (50 mg·d(−1)) and α-lipoic acid (LA, 150 mg·d(−1)), n = 9); or placebo (PL, n = 9) for 8 weeks, whilst maintaining standardised, aerobic exercise. Fat oxidation (‘FAT(MAX)’ and steady state exercise protocols), body composition, cardio-metabolic and blood measures (serum glucose, insulin, leptin, adiponectin, glycerol, free fatty acids, total cholesterol, high [HDL-c] and low-density lipoprotein cholesterol [LDL-c], triglycerides, liver enzymes and bilirubin) were assessed at baseline, week 4 and 8. Following 8 weeks of dGTE+, maximal fat oxidation (MFO) significantly improved from 154.4 ± 20.6 to 224.6 ± 23.2 mg·min(−1) (p = 0.009), along with a 22.5% increase in the exercise intensity at which fat oxidation was deemed negligible (FAT(MIN); 67.6 ± 3.6% [Formula: see text] O(2peak), p = 0.003). Steady state exercise substrate utilisation also improved for dGTE+ only, with respiratory exchange ratio reducing from 0.94 ± 0.01 at week 4, to 0.89 ± 0.01 at week 8 (p = 0.004). This corresponded with a significant increase in the contribution of fat to energy expenditure for dGTE+ from 21.0 ± 4.1% at week 4, to 34.6 ± 4.7% at week 8 (p = 0.006). LDL-c was also lower (normalised fold change of −0.09 ± 0.06) for dGTE+ by week 8 (p = 0.038). No other significant effects were found in any group. Eight weeks of dGTE+ improved MFO and substrate utilisation during exercise, and lowered LDL-c. However, body composition and cardio-metabolic markers in healthy, overweight individuals who maintained regular physical activity were largely unaffected by dGTE.
format Online
Article
Text
id pubmed-7996723
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79967232021-03-27 The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals Roberts, Justin D. Willmott, Ashley G. B. Beasley, Liam Boal, Mariette Davies, Rory Martin, Laurence Chichger, Havovi Gautam, Lata Del Coso, Juan Nutrients Article This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mass: 77.5 ± 10.5 kg; body mass index: 27.4 ± 3.0 kg·m(2); peak oxygen uptake ([Formula: see text] O(2peak)): 30.2 ± 5.8 mL·kg(−1)·min(−1)) were randomly assigned, in a double-blinded manner, either: dGTE (400 mg·d(−1) (−)-epigallocatechin−3-gallate (EGCG), n = 9); a novel dGTE+ (400 mg·d(−1) EGCG, quercetin (50 mg·d(−1)) and α-lipoic acid (LA, 150 mg·d(−1)), n = 9); or placebo (PL, n = 9) for 8 weeks, whilst maintaining standardised, aerobic exercise. Fat oxidation (‘FAT(MAX)’ and steady state exercise protocols), body composition, cardio-metabolic and blood measures (serum glucose, insulin, leptin, adiponectin, glycerol, free fatty acids, total cholesterol, high [HDL-c] and low-density lipoprotein cholesterol [LDL-c], triglycerides, liver enzymes and bilirubin) were assessed at baseline, week 4 and 8. Following 8 weeks of dGTE+, maximal fat oxidation (MFO) significantly improved from 154.4 ± 20.6 to 224.6 ± 23.2 mg·min(−1) (p = 0.009), along with a 22.5% increase in the exercise intensity at which fat oxidation was deemed negligible (FAT(MIN); 67.6 ± 3.6% [Formula: see text] O(2peak), p = 0.003). Steady state exercise substrate utilisation also improved for dGTE+ only, with respiratory exchange ratio reducing from 0.94 ± 0.01 at week 4, to 0.89 ± 0.01 at week 8 (p = 0.004). This corresponded with a significant increase in the contribution of fat to energy expenditure for dGTE+ from 21.0 ± 4.1% at week 4, to 34.6 ± 4.7% at week 8 (p = 0.006). LDL-c was also lower (normalised fold change of −0.09 ± 0.06) for dGTE+ by week 8 (p = 0.038). No other significant effects were found in any group. Eight weeks of dGTE+ improved MFO and substrate utilisation during exercise, and lowered LDL-c. However, body composition and cardio-metabolic markers in healthy, overweight individuals who maintained regular physical activity were largely unaffected by dGTE. MDPI 2021-02-26 /pmc/articles/PMC7996723/ /pubmed/33652910 http://dx.doi.org/10.3390/nu13030764 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Roberts, Justin D.
Willmott, Ashley G. B.
Beasley, Liam
Boal, Mariette
Davies, Rory
Martin, Laurence
Chichger, Havovi
Gautam, Lata
Del Coso, Juan
The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
title The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
title_full The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
title_fullStr The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
title_full_unstemmed The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
title_short The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals
title_sort impact of decaffeinated green tea extract on fat oxidation, body composition and cardio-metabolic health in overweight, recreationally active individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996723/
https://www.ncbi.nlm.nih.gov/pubmed/33652910
http://dx.doi.org/10.3390/nu13030764
work_keys_str_mv AT robertsjustind theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT willmottashleygb theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT beasleyliam theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT boalmariette theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT daviesrory theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT martinlaurence theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT chichgerhavovi theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT gautamlata theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT delcosojuan theimpactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT robertsjustind impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT willmottashleygb impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT beasleyliam impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT boalmariette impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT daviesrory impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT martinlaurence impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT chichgerhavovi impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT gautamlata impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals
AT delcosojuan impactofdecaffeinatedgreenteaextractonfatoxidationbodycompositionandcardiometabolichealthinoverweightrecreationallyactiveindividuals