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Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure

Epicardial adipose tissue (EAT) as a source of pro-inflammatory cytokines tightly linked to metabolic abnormalities. Data regarding the associations of EAT with adipocyte fatty acid-binding protein (A-FABP), a cytokine implicated in the cardiometabolic syndrome, might play an important part in media...

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Autores principales: Lin, Jiun-Lu, Sung, Kuo-Tzu, Lai, Yau-Huei, Yen, Chih-Hsuan, Yun, Chun-Ho, Su, Cheng-Huang, Kuo, Jen-Yuan, Liu, Chia-Yuan, Chien, Chen-Yen, Cury, Ricardo C., Bezerra, Hiram G., Hung, Chung-Lieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996796/
https://www.ncbi.nlm.nih.gov/pubmed/33652956
http://dx.doi.org/10.3390/diagnostics11030397
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author Lin, Jiun-Lu
Sung, Kuo-Tzu
Lai, Yau-Huei
Yen, Chih-Hsuan
Yun, Chun-Ho
Su, Cheng-Huang
Kuo, Jen-Yuan
Liu, Chia-Yuan
Chien, Chen-Yen
Cury, Ricardo C.
Bezerra, Hiram G.
Hung, Chung-Lieh
author_facet Lin, Jiun-Lu
Sung, Kuo-Tzu
Lai, Yau-Huei
Yen, Chih-Hsuan
Yun, Chun-Ho
Su, Cheng-Huang
Kuo, Jen-Yuan
Liu, Chia-Yuan
Chien, Chen-Yen
Cury, Ricardo C.
Bezerra, Hiram G.
Hung, Chung-Lieh
author_sort Lin, Jiun-Lu
collection PubMed
description Epicardial adipose tissue (EAT) as a source of pro-inflammatory cytokines tightly linked to metabolic abnormalities. Data regarding the associations of EAT with adipocyte fatty acid-binding protein (A-FABP), a cytokine implicated in the cardiometabolic syndrome, might play an important part in mediating the association between EAT and cardiac structure/function in preserved ejection fraction heart failure (HFpEF). We conducted a prospective cohort study comprising 252 prospectively enrolled study participants classified as healthy (n = 40), high-risk (n = 161), or HFpEF (n = 51). EAT was assessed using echocardiography and compared between the three groups and related to A-FABP, cardiac structural/functional assessment utilizing myocardial deformations (strain/strain rates) and HF outcomes. EAT thickness was highest in participants with HFpEF (9.7 ± 1.7 mm) and those at high-risk (8.2 ± 1.5 mm) and lowest in healthy controls (6.4 ± 1.9 mm, p < 0.001). Higher EAT correlated with the presence of cardiometabolic syndrome, diabetes and renal insufficiency independent of BMI and waist circumference (p(interaction) for all > 0.1), and was associated with reduced LV global longitudinal strain (GLS) and LV mass-independent systolic/diastolic strain rates (SRs/SRe) (all p < 0.05). Higher A-FABP levels were associated with greater EAT thickness (p(interaction) > 0.1). Importantly, in the combined control cohort, A-FABP levels mediated the association between EAT and new onset HF. Excessive EAT is independently associated with the metabolic syndrome, renal insufficiency, and higher A-FABP levels. The association between EAT and new onset HF is mediated by A-FABP, suggesting a metabolic link between EAT and HF.
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spelling pubmed-79967962021-03-27 Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure Lin, Jiun-Lu Sung, Kuo-Tzu Lai, Yau-Huei Yen, Chih-Hsuan Yun, Chun-Ho Su, Cheng-Huang Kuo, Jen-Yuan Liu, Chia-Yuan Chien, Chen-Yen Cury, Ricardo C. Bezerra, Hiram G. Hung, Chung-Lieh Diagnostics (Basel) Article Epicardial adipose tissue (EAT) as a source of pro-inflammatory cytokines tightly linked to metabolic abnormalities. Data regarding the associations of EAT with adipocyte fatty acid-binding protein (A-FABP), a cytokine implicated in the cardiometabolic syndrome, might play an important part in mediating the association between EAT and cardiac structure/function in preserved ejection fraction heart failure (HFpEF). We conducted a prospective cohort study comprising 252 prospectively enrolled study participants classified as healthy (n = 40), high-risk (n = 161), or HFpEF (n = 51). EAT was assessed using echocardiography and compared between the three groups and related to A-FABP, cardiac structural/functional assessment utilizing myocardial deformations (strain/strain rates) and HF outcomes. EAT thickness was highest in participants with HFpEF (9.7 ± 1.7 mm) and those at high-risk (8.2 ± 1.5 mm) and lowest in healthy controls (6.4 ± 1.9 mm, p < 0.001). Higher EAT correlated with the presence of cardiometabolic syndrome, diabetes and renal insufficiency independent of BMI and waist circumference (p(interaction) for all > 0.1), and was associated with reduced LV global longitudinal strain (GLS) and LV mass-independent systolic/diastolic strain rates (SRs/SRe) (all p < 0.05). Higher A-FABP levels were associated with greater EAT thickness (p(interaction) > 0.1). Importantly, in the combined control cohort, A-FABP levels mediated the association between EAT and new onset HF. Excessive EAT is independently associated with the metabolic syndrome, renal insufficiency, and higher A-FABP levels. The association between EAT and new onset HF is mediated by A-FABP, suggesting a metabolic link between EAT and HF. MDPI 2021-02-26 /pmc/articles/PMC7996796/ /pubmed/33652956 http://dx.doi.org/10.3390/diagnostics11030397 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Lin, Jiun-Lu
Sung, Kuo-Tzu
Lai, Yau-Huei
Yen, Chih-Hsuan
Yun, Chun-Ho
Su, Cheng-Huang
Kuo, Jen-Yuan
Liu, Chia-Yuan
Chien, Chen-Yen
Cury, Ricardo C.
Bezerra, Hiram G.
Hung, Chung-Lieh
Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure
title Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure
title_full Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure
title_fullStr Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure
title_full_unstemmed Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure
title_short Epicardial Adiposity in Relation to Metabolic Abnormality, Circulating Adipocyte FABP, and Preserved Ejection Fraction Heart Failure
title_sort epicardial adiposity in relation to metabolic abnormality, circulating adipocyte fabp, and preserved ejection fraction heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996796/
https://www.ncbi.nlm.nih.gov/pubmed/33652956
http://dx.doi.org/10.3390/diagnostics11030397
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