Cargando…

The Design and Preclinical Evaluation of a Single-Label Bimodal Nanobody Tracer for Image-Guided Surgery

Intraoperative guidance using targeted fluorescent tracers can potentially provide surgeons with real-time feedback on the presence of tumor tissue in resection margins. To overcome the limited depth penetration of fluorescent light, combining fluorescence with SPECT/CT imaging and/or gamma-ray trac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Debie, Pieterjan, Declerck, Noemi B., van Willigen, Danny, Huygen, Celine M., De Sloovere, Bieke, Mateusiak, Lukasz, Bridoux, Jessica, Puttemans, Janik, Devoogdt, Nick, van Leeuwen, Fijs W. B., Hernot, Sophie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996797/ https://www.ncbi.nlm.nih.gov/pubmed/33652977 http://dx.doi.org/10.3390/biom11030360

Ejemplares similares

Targeted Nanobody-Based Molecular Tracers for Nuclear Imaging and Image-Guided Surgery
por: Debie, Pieterjan, et al.
Publicado: (2019)

The GEM-handle as convenient labeling strategy for bimodal single-domain antibody-based tracers carrying (99m)Tc and a near-infrared fluorescent dye for intra-operative decision-making
por: Declerck, Noemi B., et al.
Publicado: (2023)

Emerging Fluorescent Molecular Tracers to Guide Intra-Operative Surgical Decision-Making
por: Debie, Pieterjan, et al.
Publicado: (2019)

Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality
por: Baudhuin, Henri, et al.
Publicado: (2021)

Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting
por: Erreni, Marco, et al.
Publicado: (2023)

Anti-Human PD-L1 Nanobody for Immuno-PET Imaging: Validation of a Conjugation Strategy for Clinical Translation
por: Bridoux, Jessica, et al.
Publicado: (2020)

Improved Detection of Molecular Markers of Atherosclerotic Plaques Using Sub-Millimeter PET Imaging
por: Bridoux, Jessica, et al.
Publicado: (2020)

Intraoperative visualization of nerves using a myelin protein-zero specific fluorescent tracer
por: Buckle, Tessa, et al.
Publicado: (2021)

Three-way multiplexing in prostate cancer patients — combining a bimodal sentinel node tracer with multicolor fluorescence imaging
por: Berrens, Anne-Claire, et al.
Publicado: (2022)

Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?
por: Hensbergen, Albertus Wijnand, et al.
Publicado: (2019)

Click Chemistry in the Design and Production of Hybrid Tracers
por: Hensbergen, Albertus W., et al.
Publicado: (2019)

Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using a Fluorescently Labelled Anti-CEA Nanobody Probe: A Preclinical Study
por: van Manen, Labrinus, et al.
Publicado: (2023)

Targeted alpha therapy using short-lived alpha-particles and the promise of nanobodies as targeting vehicle
por: Dekempeneer, Yana, et al.
Publicado: (2016)

Development and evaluation of nanobody tracers for noninvasive nuclear imaging of the immune-checkpoint TIGIT
por: Zeven, Katty, et al.
Publicado: (2023)

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha
por: De Vlaminck, Karen, et al.
Publicado: (2021)

Evaluation of single domain antibodies as nuclear tracers for imaging of the immune checkpoint receptor human lymphocyte activation gene-3 in cancer
por: Lecocq, Q., et al.
Publicado: (2021)

Feasibility of fluorescence imaging at microdosing using a hybrid PSMA tracer during robot-assisted radical prostatectomy in a large animal model
por: Dell’Oglio, Paolo, et al.
Publicado: (2022)

Safety assessment of fluorescently labeled anti-EGFR Nanobodies in healthy dogs
por: do Valle, Nayra Cristina Herreira, et al.
Publicado: (2023)

Preclinical Targeted α- and β(−)-Radionuclide Therapy in HER2-Positive Brain Metastasis Using Camelid Single-Domain Antibodies
por: Puttemans, Janik, et al.
Publicado: (2020)

Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant
por: Duszenko, Nikolas, et al.
Publicado: (2022)

Non-invasive assessment of murine PD-L1 levels in syngeneic tumor models by nuclear imaging with nanobody tracers
por: Broos, Katrijn, et al.
Publicado: (2017)

Beyond the Barrier: Targeted Radionuclide Therapy in Brain Tumors and Metastases
por: Puttemans, Janik, et al.
Publicado: (2019)

uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery
por: Boonstra, Martin C., et al.
Publicado: (2015)

Site-Specific Radiolabeling of a Human PD-L1 Nanobody via Maleimide–Cysteine Chemistry
por: Chigoho, Dora Mugoli, et al.
Publicado: (2021)

The Road to Personalized Myeloma Medicine: Patient-specific Single-domain Antibodies for Anti-idiotypic Radionuclide Therapy
por: Puttemans, Janik, et al.
Publicado: (2022)

Fluorescence background quenching as a means to increase Signal to Background ratio - a proof of concept during Nerve Imaging
por: Buckle, Tessa, et al.
Publicado: (2020)

Comparison of two hybrid sentinel node tracers: indocyanine green (ICG)-(99m)Tc-nanocolloid vs. ICG-(99m)Tc-nanoscan from a nuclear medicine and surgical perspective
por: Vreeburg, Manon T. A., et al.
Publicado: (2023)

Cyclodextrin/Adamantane-Mediated Targeting of Inoculated Bacteria in Mice
por: Welling, Mick M., et al.
Publicado: (2021)

Authentically radiolabelled Mn(II) complexes as bimodal PET/MR tracers
por: Vanasschen, Christian, et al.
Publicado: (2015)

A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
por: Balhuizen, Alexander, et al.
Publicado: (2017)

Fluorescence guided surgery and tracer-dose, fact or fiction?
por: KleinJan, Gijs H., et al.
Publicado: (2016)

Generation of fluorescently labeled tracers – which features influence the translational potential?
por: van Leeuwen, Fijs W. B., et al.
Publicado: (2017)

Biocompatible branched copolymer nanoparticles prepared by RAFT polymerization as MRI/PET bimodal tracers
por: Yang, Chang-Tong, et al.
Publicado: (2015)

DiI-CT—A bimodal neural tracer for X-ray and fluorescence imaging
por: Gerhardt, Ben, et al.
Publicado: (2023)

Development and Characterization of Nanobodies Targeting the Kupffer Cell
por: Zheng, Fang, et al.
Publicado: (2021)

A Supramolecular Platform Technology for Bacterial Cell Surface Modification
por: Duszenko, Nikolas, et al.
Publicado: (2020)

Fluorescent Lectins for Local in Vivo Visualization of Peripheral Nerves
por: KleinJan, Gijs Hendrik, et al.
Publicado: (2014)

Obtaining control of cell surface functionalizations via Pre-targeting and Supramolecular host guest interactions
por: Rood, Mark T. M., et al.
Publicado: (2017)

Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis
por: Senders, Max L., et al.
Publicado: (2018)

Nanobodies for the Early Detection of Ovarian Cancer
por: Tran, Lan-Huong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2ttdlimpvnmsvdn82j6rjr68gr