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Animal Coronaviruses Induced Apoptosis
Apoptosis is a form of programmed death that has also been observed in cells infected by several viruses. It is considered one of the most critical innate immune mechanisms that limits pathogen proliferation and propagation before the initiation of the adaptive immune response. Recent studies invest...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996831/ https://www.ncbi.nlm.nih.gov/pubmed/33652685 http://dx.doi.org/10.3390/life11030185 |
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author | Gioti, Katerina Kottaridi, Christine Voyiatzaki, Chrysa Chaniotis, Dimitrios Rampias, Theodoros Beloukas, Apostolos |
author_facet | Gioti, Katerina Kottaridi, Christine Voyiatzaki, Chrysa Chaniotis, Dimitrios Rampias, Theodoros Beloukas, Apostolos |
author_sort | Gioti, Katerina |
collection | PubMed |
description | Apoptosis is a form of programmed death that has also been observed in cells infected by several viruses. It is considered one of the most critical innate immune mechanisms that limits pathogen proliferation and propagation before the initiation of the adaptive immune response. Recent studies investigating the cellular responses to SARS-CoV and SARS-CoV-2 infection have revealed that coronaviruses can alter cellular homeostasis and promote cell death, providing evidence that the modulation of apoptotic pathways is important for viral replication and propagation. Despite the genetic diversity among different coronavirus clades and the infection of different cell types and several hosts, research studies in animal coronaviruses indicate that apoptosis in host cells is induced by common molecular mechanisms and apoptotic pathways. We summarize and critically review current knowledge on the molecular aspects of cell-death regulation during animal coronaviruses infection and the viral–host interactions to this process. Future research is expected to lead to a better understanding of the regulation of cell death during coronavirus infection. Moreover, investigating the role of viral proteins in this process will help us to identify novel antiviral targets related to apoptotic signaling pathways. |
format | Online Article Text |
id | pubmed-7996831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79968312021-03-27 Animal Coronaviruses Induced Apoptosis Gioti, Katerina Kottaridi, Christine Voyiatzaki, Chrysa Chaniotis, Dimitrios Rampias, Theodoros Beloukas, Apostolos Life (Basel) Review Apoptosis is a form of programmed death that has also been observed in cells infected by several viruses. It is considered one of the most critical innate immune mechanisms that limits pathogen proliferation and propagation before the initiation of the adaptive immune response. Recent studies investigating the cellular responses to SARS-CoV and SARS-CoV-2 infection have revealed that coronaviruses can alter cellular homeostasis and promote cell death, providing evidence that the modulation of apoptotic pathways is important for viral replication and propagation. Despite the genetic diversity among different coronavirus clades and the infection of different cell types and several hosts, research studies in animal coronaviruses indicate that apoptosis in host cells is induced by common molecular mechanisms and apoptotic pathways. We summarize and critically review current knowledge on the molecular aspects of cell-death regulation during animal coronaviruses infection and the viral–host interactions to this process. Future research is expected to lead to a better understanding of the regulation of cell death during coronavirus infection. Moreover, investigating the role of viral proteins in this process will help us to identify novel antiviral targets related to apoptotic signaling pathways. MDPI 2021-02-26 /pmc/articles/PMC7996831/ /pubmed/33652685 http://dx.doi.org/10.3390/life11030185 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Gioti, Katerina Kottaridi, Christine Voyiatzaki, Chrysa Chaniotis, Dimitrios Rampias, Theodoros Beloukas, Apostolos Animal Coronaviruses Induced Apoptosis |
title | Animal Coronaviruses Induced Apoptosis |
title_full | Animal Coronaviruses Induced Apoptosis |
title_fullStr | Animal Coronaviruses Induced Apoptosis |
title_full_unstemmed | Animal Coronaviruses Induced Apoptosis |
title_short | Animal Coronaviruses Induced Apoptosis |
title_sort | animal coronaviruses induced apoptosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996831/ https://www.ncbi.nlm.nih.gov/pubmed/33652685 http://dx.doi.org/10.3390/life11030185 |
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