Cargando…

Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis

The C-reactive protein-to-albumin ratio is a proven prognostic predictor of nasopharyngeal carcinoma. However, the role of the C-reactive protein-to-albumin ratio in other head and neck cancers remains unclear. This meta-analysis explored the prognostic value of the C-reactive protein-to-albumin rat...

Descripción completa

Detalles Bibliográficos
Autores principales: Luan, Chih-Wei, Yang, Hsin-Yi, Tsai, Yao-Te, Hsieh, Meng-Chiao, Chou, Hsin-Hsu, Chen, Kuo-Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996835/
https://www.ncbi.nlm.nih.gov/pubmed/33652976
http://dx.doi.org/10.3390/diagnostics11030403
_version_ 1783670191064875008
author Luan, Chih-Wei
Yang, Hsin-Yi
Tsai, Yao-Te
Hsieh, Meng-Chiao
Chou, Hsin-Hsu
Chen, Kuo-Su
author_facet Luan, Chih-Wei
Yang, Hsin-Yi
Tsai, Yao-Te
Hsieh, Meng-Chiao
Chou, Hsin-Hsu
Chen, Kuo-Su
author_sort Luan, Chih-Wei
collection PubMed
description The C-reactive protein-to-albumin ratio is a proven prognostic predictor of nasopharyngeal carcinoma. However, the role of the C-reactive protein-to-albumin ratio in other head and neck cancers remains unclear. This meta-analysis explored the prognostic value of the C-reactive protein-to-albumin ratio in head and neck cancers. A systematic search was conducted. Outcomes of interest included overall survival, disease-free survival, and distant metastasis–free survival. The hazard ratio with 95% confidence interval was pooled using a random-effects model. A total of 11 publications from the literature were included, allowing for the analysis of 7080 participants. Data pooling demonstrated that pretreatment C-reactive protein-to-albumin ratio had a hazard ratio of 1.88 (95% CI: 1.49−2.37, p < 0.001) for predicting overall survival, 1.91 (95% CI: 1.18−3.08, p = 0.002) for disease-free survival, and 1.46 (95% CI: 1.08−1.96, p = 0.001) for distant metastasis–free survival. Subgroup analysis showed that the C-reactive protein-to-albumin ratio is a significant prognostic marker for various head and neck cancers. An elevated pretreatment C-reactive protein-to-albumin ratio predicts a worse prognosis for patients with head and neck cancers. Therefore, the C-reactive protein-to-albumin ratio could serve as a potential prognostic biomarker facilitating treatment stratification.
format Online
Article
Text
id pubmed-7996835
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79968352021-03-27 Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis Luan, Chih-Wei Yang, Hsin-Yi Tsai, Yao-Te Hsieh, Meng-Chiao Chou, Hsin-Hsu Chen, Kuo-Su Diagnostics (Basel) Review The C-reactive protein-to-albumin ratio is a proven prognostic predictor of nasopharyngeal carcinoma. However, the role of the C-reactive protein-to-albumin ratio in other head and neck cancers remains unclear. This meta-analysis explored the prognostic value of the C-reactive protein-to-albumin ratio in head and neck cancers. A systematic search was conducted. Outcomes of interest included overall survival, disease-free survival, and distant metastasis–free survival. The hazard ratio with 95% confidence interval was pooled using a random-effects model. A total of 11 publications from the literature were included, allowing for the analysis of 7080 participants. Data pooling demonstrated that pretreatment C-reactive protein-to-albumin ratio had a hazard ratio of 1.88 (95% CI: 1.49−2.37, p < 0.001) for predicting overall survival, 1.91 (95% CI: 1.18−3.08, p = 0.002) for disease-free survival, and 1.46 (95% CI: 1.08−1.96, p = 0.001) for distant metastasis–free survival. Subgroup analysis showed that the C-reactive protein-to-albumin ratio is a significant prognostic marker for various head and neck cancers. An elevated pretreatment C-reactive protein-to-albumin ratio predicts a worse prognosis for patients with head and neck cancers. Therefore, the C-reactive protein-to-albumin ratio could serve as a potential prognostic biomarker facilitating treatment stratification. MDPI 2021-02-26 /pmc/articles/PMC7996835/ /pubmed/33652976 http://dx.doi.org/10.3390/diagnostics11030403 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Luan, Chih-Wei
Yang, Hsin-Yi
Tsai, Yao-Te
Hsieh, Meng-Chiao
Chou, Hsin-Hsu
Chen, Kuo-Su
Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
title Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
title_full Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
title_fullStr Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
title_full_unstemmed Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
title_short Prognostic Value of C-Reactive Protein-to-Albumin Ratio in Head and Neck Cancer: A Meta-Analysis
title_sort prognostic value of c-reactive protein-to-albumin ratio in head and neck cancer: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996835/
https://www.ncbi.nlm.nih.gov/pubmed/33652976
http://dx.doi.org/10.3390/diagnostics11030403
work_keys_str_mv AT luanchihwei prognosticvalueofcreactiveproteintoalbuminratioinheadandneckcancerametaanalysis
AT yanghsinyi prognosticvalueofcreactiveproteintoalbuminratioinheadandneckcancerametaanalysis
AT tsaiyaote prognosticvalueofcreactiveproteintoalbuminratioinheadandneckcancerametaanalysis
AT hsiehmengchiao prognosticvalueofcreactiveproteintoalbuminratioinheadandneckcancerametaanalysis
AT chouhsinhsu prognosticvalueofcreactiveproteintoalbuminratioinheadandneckcancerametaanalysis
AT chenkuosu prognosticvalueofcreactiveproteintoalbuminratioinheadandneckcancerametaanalysis