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Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T

Using glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) magnetic resonance imaging (MRI), this study comparatively evaluated the GAG contents of lumbar intervertebral disks (IVDs) of patients with non-specific low back pain (nsLBP), radiculopathy, and asymptomatic volunteers to eluci...

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Autores principales: Frenken, Miriam, Nebelung, Sven, Schleich, Christoph, Müller-Lutz, Anja, Radke, Karl Ludger, Kamp, Benedikt, Boschheidgen, Matthias, Wollschläger, Lena, Bittersohl, Bernd, Antoch, Gerald, Konieczny, Markus R., Abrar, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996864/
https://www.ncbi.nlm.nih.gov/pubmed/33652924
http://dx.doi.org/10.3390/diagnostics11030402
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author Frenken, Miriam
Nebelung, Sven
Schleich, Christoph
Müller-Lutz, Anja
Radke, Karl Ludger
Kamp, Benedikt
Boschheidgen, Matthias
Wollschläger, Lena
Bittersohl, Bernd
Antoch, Gerald
Konieczny, Markus R.
Abrar, Daniel B.
author_facet Frenken, Miriam
Nebelung, Sven
Schleich, Christoph
Müller-Lutz, Anja
Radke, Karl Ludger
Kamp, Benedikt
Boschheidgen, Matthias
Wollschläger, Lena
Bittersohl, Bernd
Antoch, Gerald
Konieczny, Markus R.
Abrar, Daniel B.
author_sort Frenken, Miriam
collection PubMed
description Using glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) magnetic resonance imaging (MRI), this study comparatively evaluated the GAG contents of lumbar intervertebral disks (IVDs) of patients with non-specific low back pain (nsLBP), radiculopathy, and asymptomatic volunteers to elucidate the association of clinical manifestation and compositional correlate. A total of 18 patients (mean age 57.5 ± 22.5 years) with radiculopathy, 16 age-matched patients with chronic nsLBP and 20 age-matched volunteers underwent standard morphologic and compositional gagCEST MRI on a 3T scanner. In all cohorts, GAG contents of lumbar IVDs were determined using gagCEST MRI. An assessment of morphologic IVD degeneration based on the Pfirrmann classification and T2-weighted sequences served as a reference. A linear mixed model adjusted for multiple confounders was used for statistical evaluation. IVDs of patients with nsLBP showed lower gagCEST values than those of volunteers (nsLBP: 1.3% [99% confidence intervals (CI): 1.0; 1.6] vs. volunteers: 1.9% [99% CI: 1.6; 2.2]). Yet, IVDs of patients with radiculopathy (1.8% [99% CI: 1.4; 2.1]) were not different from patients with nsLBP or volunteers. In patients with radiculopathy, IVDs directly adjacent to IVD extrusions demonstrated lower gagCEST values than distant IVDs (adjacent: 0.9% [99% CI: 0.3; 1.5], distant: 2.1% [99% CI: 1.7; 2.5]). Advanced GAG depletion in nsLBP and directly adjacent to IVD extrusions in radiculopathy indicates close interrelatedness of clinical pathology and compositional degeneration.
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spelling pubmed-79968642021-03-27 Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T Frenken, Miriam Nebelung, Sven Schleich, Christoph Müller-Lutz, Anja Radke, Karl Ludger Kamp, Benedikt Boschheidgen, Matthias Wollschläger, Lena Bittersohl, Bernd Antoch, Gerald Konieczny, Markus R. Abrar, Daniel B. Diagnostics (Basel) Article Using glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) magnetic resonance imaging (MRI), this study comparatively evaluated the GAG contents of lumbar intervertebral disks (IVDs) of patients with non-specific low back pain (nsLBP), radiculopathy, and asymptomatic volunteers to elucidate the association of clinical manifestation and compositional correlate. A total of 18 patients (mean age 57.5 ± 22.5 years) with radiculopathy, 16 age-matched patients with chronic nsLBP and 20 age-matched volunteers underwent standard morphologic and compositional gagCEST MRI on a 3T scanner. In all cohorts, GAG contents of lumbar IVDs were determined using gagCEST MRI. An assessment of morphologic IVD degeneration based on the Pfirrmann classification and T2-weighted sequences served as a reference. A linear mixed model adjusted for multiple confounders was used for statistical evaluation. IVDs of patients with nsLBP showed lower gagCEST values than those of volunteers (nsLBP: 1.3% [99% confidence intervals (CI): 1.0; 1.6] vs. volunteers: 1.9% [99% CI: 1.6; 2.2]). Yet, IVDs of patients with radiculopathy (1.8% [99% CI: 1.4; 2.1]) were not different from patients with nsLBP or volunteers. In patients with radiculopathy, IVDs directly adjacent to IVD extrusions demonstrated lower gagCEST values than distant IVDs (adjacent: 0.9% [99% CI: 0.3; 1.5], distant: 2.1% [99% CI: 1.7; 2.5]). Advanced GAG depletion in nsLBP and directly adjacent to IVD extrusions in radiculopathy indicates close interrelatedness of clinical pathology and compositional degeneration. MDPI 2021-02-26 /pmc/articles/PMC7996864/ /pubmed/33652924 http://dx.doi.org/10.3390/diagnostics11030402 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Frenken, Miriam
Nebelung, Sven
Schleich, Christoph
Müller-Lutz, Anja
Radke, Karl Ludger
Kamp, Benedikt
Boschheidgen, Matthias
Wollschläger, Lena
Bittersohl, Bernd
Antoch, Gerald
Konieczny, Markus R.
Abrar, Daniel B.
Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T
title Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T
title_full Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T
title_fullStr Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T
title_full_unstemmed Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T
title_short Non-Specific Low Back Pain and Lumbar Radiculopathy: Comparison of Morphologic and Compositional MRI as Assessed by gagCEST Imaging at 3T
title_sort non-specific low back pain and lumbar radiculopathy: comparison of morphologic and compositional mri as assessed by gagcest imaging at 3t
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996864/
https://www.ncbi.nlm.nih.gov/pubmed/33652924
http://dx.doi.org/10.3390/diagnostics11030402
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