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Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
Neurodegenerative change in the central nervous system has been suggested as one of the pathophysiological mechanisms of autonomic nervous system dysfunction in Parkinson’s disease (PD). We analyzed gray matter (GM) volume changes and clinical parameters in patients with PD to investigate any involv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996881/ https://www.ncbi.nlm.nih.gov/pubmed/33652757 http://dx.doi.org/10.3390/brainsci11030294 |
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author | Kim, Jung Bin Kim, Hayom Lee, Chan-Nyung Park, Kun-Woo Kim, Byung-Jo |
author_facet | Kim, Jung Bin Kim, Hayom Lee, Chan-Nyung Park, Kun-Woo Kim, Byung-Jo |
author_sort | Kim, Jung Bin |
collection | PubMed |
description | Neurodegenerative change in the central nervous system has been suggested as one of the pathophysiological mechanisms of autonomic nervous system dysfunction in Parkinson’s disease (PD). We analyzed gray matter (GM) volume changes and clinical parameters in patients with PD to investigate any involvement in the brain structures responsible for autonomic control in patients with PD having orthostatic hypotension (OH). Voxel-based morphometry was applied to compare regional GM volumes between PD patients with and without OH. Multivariate logistic regression analysis using a hierarchical model was carried out to identify clinical factors independently contributing to the regional GM volume changes in PD patients with OH. The Sobel test was used to analyze mediation effects between the independent contributing factors to the GM volume changes. PD patients with OH had more severe autonomic dysfunction and reduction in volume in the right inferior temporal cortex than those without OH. The right inferior temporal volume was positively correlated with the Qualitative Scoring MMSE Pentagon Test (QSPT) score, reflecting visuospatial/visuoperceptual function, and negatively correlated with the Composite Autonomic Severity Score (CASS). The CASS and QSPT scores were found to be factors independently contributing to regional volume changes in the right inferior temporal cortex. The QSPT score was identified as a mediator in which regional GM volume predicts the CASS. Our findings suggest that a decrease in the visuospatial/visuoperceptual process may be involved in the presentation of autonomic nervous system dysfunction in PD patients. |
format | Online Article Text |
id | pubmed-7996881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79968812021-03-27 Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension Kim, Jung Bin Kim, Hayom Lee, Chan-Nyung Park, Kun-Woo Kim, Byung-Jo Brain Sci Article Neurodegenerative change in the central nervous system has been suggested as one of the pathophysiological mechanisms of autonomic nervous system dysfunction in Parkinson’s disease (PD). We analyzed gray matter (GM) volume changes and clinical parameters in patients with PD to investigate any involvement in the brain structures responsible for autonomic control in patients with PD having orthostatic hypotension (OH). Voxel-based morphometry was applied to compare regional GM volumes between PD patients with and without OH. Multivariate logistic regression analysis using a hierarchical model was carried out to identify clinical factors independently contributing to the regional GM volume changes in PD patients with OH. The Sobel test was used to analyze mediation effects between the independent contributing factors to the GM volume changes. PD patients with OH had more severe autonomic dysfunction and reduction in volume in the right inferior temporal cortex than those without OH. The right inferior temporal volume was positively correlated with the Qualitative Scoring MMSE Pentagon Test (QSPT) score, reflecting visuospatial/visuoperceptual function, and negatively correlated with the Composite Autonomic Severity Score (CASS). The CASS and QSPT scores were found to be factors independently contributing to regional volume changes in the right inferior temporal cortex. The QSPT score was identified as a mediator in which regional GM volume predicts the CASS. Our findings suggest that a decrease in the visuospatial/visuoperceptual process may be involved in the presentation of autonomic nervous system dysfunction in PD patients. MDPI 2021-02-26 /pmc/articles/PMC7996881/ /pubmed/33652757 http://dx.doi.org/10.3390/brainsci11030294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Article Kim, Jung Bin Kim, Hayom Lee, Chan-Nyung Park, Kun-Woo Kim, Byung-Jo Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension |
title | Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension |
title_full | Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension |
title_fullStr | Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension |
title_full_unstemmed | Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension |
title_short | Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension |
title_sort | regional gray matter volume changes in parkinson’s disease with orthostatic hypotension |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996881/ https://www.ncbi.nlm.nih.gov/pubmed/33652757 http://dx.doi.org/10.3390/brainsci11030294 |
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