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Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension

Neurodegenerative change in the central nervous system has been suggested as one of the pathophysiological mechanisms of autonomic nervous system dysfunction in Parkinson’s disease (PD). We analyzed gray matter (GM) volume changes and clinical parameters in patients with PD to investigate any involv...

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Autores principales: Kim, Jung Bin, Kim, Hayom, Lee, Chan-Nyung, Park, Kun-Woo, Kim, Byung-Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996881/
https://www.ncbi.nlm.nih.gov/pubmed/33652757
http://dx.doi.org/10.3390/brainsci11030294
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author Kim, Jung Bin
Kim, Hayom
Lee, Chan-Nyung
Park, Kun-Woo
Kim, Byung-Jo
author_facet Kim, Jung Bin
Kim, Hayom
Lee, Chan-Nyung
Park, Kun-Woo
Kim, Byung-Jo
author_sort Kim, Jung Bin
collection PubMed
description Neurodegenerative change in the central nervous system has been suggested as one of the pathophysiological mechanisms of autonomic nervous system dysfunction in Parkinson’s disease (PD). We analyzed gray matter (GM) volume changes and clinical parameters in patients with PD to investigate any involvement in the brain structures responsible for autonomic control in patients with PD having orthostatic hypotension (OH). Voxel-based morphometry was applied to compare regional GM volumes between PD patients with and without OH. Multivariate logistic regression analysis using a hierarchical model was carried out to identify clinical factors independently contributing to the regional GM volume changes in PD patients with OH. The Sobel test was used to analyze mediation effects between the independent contributing factors to the GM volume changes. PD patients with OH had more severe autonomic dysfunction and reduction in volume in the right inferior temporal cortex than those without OH. The right inferior temporal volume was positively correlated with the Qualitative Scoring MMSE Pentagon Test (QSPT) score, reflecting visuospatial/visuoperceptual function, and negatively correlated with the Composite Autonomic Severity Score (CASS). The CASS and QSPT scores were found to be factors independently contributing to regional volume changes in the right inferior temporal cortex. The QSPT score was identified as a mediator in which regional GM volume predicts the CASS. Our findings suggest that a decrease in the visuospatial/visuoperceptual process may be involved in the presentation of autonomic nervous system dysfunction in PD patients.
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spelling pubmed-79968812021-03-27 Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension Kim, Jung Bin Kim, Hayom Lee, Chan-Nyung Park, Kun-Woo Kim, Byung-Jo Brain Sci Article Neurodegenerative change in the central nervous system has been suggested as one of the pathophysiological mechanisms of autonomic nervous system dysfunction in Parkinson’s disease (PD). We analyzed gray matter (GM) volume changes and clinical parameters in patients with PD to investigate any involvement in the brain structures responsible for autonomic control in patients with PD having orthostatic hypotension (OH). Voxel-based morphometry was applied to compare regional GM volumes between PD patients with and without OH. Multivariate logistic regression analysis using a hierarchical model was carried out to identify clinical factors independently contributing to the regional GM volume changes in PD patients with OH. The Sobel test was used to analyze mediation effects between the independent contributing factors to the GM volume changes. PD patients with OH had more severe autonomic dysfunction and reduction in volume in the right inferior temporal cortex than those without OH. The right inferior temporal volume was positively correlated with the Qualitative Scoring MMSE Pentagon Test (QSPT) score, reflecting visuospatial/visuoperceptual function, and negatively correlated with the Composite Autonomic Severity Score (CASS). The CASS and QSPT scores were found to be factors independently contributing to regional volume changes in the right inferior temporal cortex. The QSPT score was identified as a mediator in which regional GM volume predicts the CASS. Our findings suggest that a decrease in the visuospatial/visuoperceptual process may be involved in the presentation of autonomic nervous system dysfunction in PD patients. MDPI 2021-02-26 /pmc/articles/PMC7996881/ /pubmed/33652757 http://dx.doi.org/10.3390/brainsci11030294 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Kim, Jung Bin
Kim, Hayom
Lee, Chan-Nyung
Park, Kun-Woo
Kim, Byung-Jo
Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
title Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
title_full Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
title_fullStr Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
title_full_unstemmed Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
title_short Regional Gray Matter Volume Changes in Parkinson’s Disease with Orthostatic Hypotension
title_sort regional gray matter volume changes in parkinson’s disease with orthostatic hypotension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996881/
https://www.ncbi.nlm.nih.gov/pubmed/33652757
http://dx.doi.org/10.3390/brainsci11030294
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