Cargando…

Cerebrospinal Fluid Parameters in Antisense Oligonucleotide-Treated Adult 5q-Spinal Muscular Atrophy Patients

Approval of nusinersen, an intrathecally administered antisense oligonucleotide, for the treatment of 5q-spinal muscular atrophy (SMA) marked the beginning of a new therapeutic era in neurological diseases. Changes in routine cerebrospinal fluid (CSF) parameters under nusinersen have only recently b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Müschen, Lars Hendrik, Osmanovic, Alma, Binz, Camilla, Jendretzky, Konstantin F., Ranxha, Gresa, Bronzlik, Paul, Abu-Fares, Omar, Wiehler, Flavia, Möhn, Nora, Hümmert, Martin W., Gingele, Stefan, Götz, Friedrich, Stangel, Martin, Skripuletz, Thomas, Schreiber-Katz, Olivia, Petri, Susanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996901/ https://www.ncbi.nlm.nih.gov/pubmed/33652830 http://dx.doi.org/10.3390/brainsci11030296

Ejemplares similares

Routine Cerebrospinal Fluid Cytology Reveals Unique Inclusions in Macrophages During Treatment With Nusinersen
por: Gingele, Stefan, et al.
Publicado: (2019)

Treatment expectations and patient-reported outcomes of nusinersen therapy in adult spinal muscular atrophy
por: Osmanovic, Alma, et al.
Publicado: (2020)

An observational cohort study on impact, dimensions and outcome of perceived fatigue in adult 5q-spinal muscular atrophy patients receiving nusinersen treatment
por: Binz, Camilla, et al.
Publicado: (2020)

The Influence of the Ventricular-Lumbar Gradient on Cerebrospinal Fluid Analysis in Serial Samples
por: Konen, Franz Felix, et al.
Publicado: (2022)

The relevance of NMDA receptor antibody-specific index for diagnosis and prognosis in patients with anti-NMDA receptor encephalitis
por: Hümmert, Martin W., et al.
Publicado: (2023)

The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid
por: Konen, Franz F, et al.
Publicado: (2021)

Improvement of muscle strength in specific muscular regions in nusinersen-treated adult patients with 5q-spinal muscular atrophy
por: Schreiber-Katz, Olivia, et al.
Publicado: (2023)

Immunophenotyping of cerebrospinal fluid cells by Chipcytometry
por: Hümmert, Martin W., et al.
Publicado: (2018)

Treatment satisfaction in 5q-spinal muscular atrophy under nusinersen therapy
por: Osmanovic, Alma, et al.
Publicado: (2021)

Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model
por: Gingele, Stefan, et al.
Publicado: (2020)

Severe Anti-N-Methyl-D-Aspartate Receptor Encephalitis Under Immunosuppression After Liver Transplantation
por: Konen, Franz Felix, et al.
Publicado: (2019)

Ocrelizumab Depletes CD20(+) T Cells in Multiple Sclerosis Patients
por: Gingele, Stefan, et al.
Publicado: (2018)

Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
por: Pannewitz-Makaj, Katharina, et al.
Publicado: (2020)

Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2019)

Investigation of Oligoclonal IgG Bands in Tear Fluid of Multiple Sclerosis Patients
por: Hümmert, Martin W., et al.
Publicado: (2019)

Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications
por: Konen, Franz Felix, et al.
Publicado: (2022)

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
por: Gudi, Viktoria, et al.
Publicado: (2014)

Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantation
por: Hümmert, Martin W., et al.
Publicado: (2021)

Executive function is inversely correlated with physical function: the cognitive profile of adult Spinal Muscular Atrophy (SMA)
por: Mix, Lucas, et al.
Publicado: (2021)

Costs of illness in amyotrophic lateral sclerosis (ALS): a cross-sectional survey in Germany
por: Schönfelder, Erik, et al.
Publicado: (2020)

Targeted metabolomic profiling of cerebrospinal fluid from patients with progressive multifocal leukoencephalopathy
por: Luo, Yi, et al.
Publicado: (2020)

The Persisting Significance of Oligoclonal Bands in the Dawning Era of Kappa Free Light Chains for the Diagnosis of Multiple Sclerosis
por: Schwenkenbecher, Philipp, et al.
Publicado: (2018)

The Impact of Immunomodulatory Treatment on Kappa Free Light Chains as Biomarker in Neuroinflammation
por: Konen, Franz Felix, et al.
Publicado: (2020)

Leptomeningeal Metastasis: The Role of Cerebrospinal Fluid Diagnostics
por: Bönig, Lena, et al.
Publicado: (2019)

Switch from intravenous to subcutaneous immunoglobulin IgPro20 in CIDP patients: a prospective observational study under real-world conditions
por: Gingele, Stefan, et al.
Publicado: (2021)

Kappa Free Light Chains in Cerebrospinal Fluid in Inflammatory and Non-Inflammatory Neurological Diseases
por: Konen, Franz Felix, et al.
Publicado: (2022)

Regenerative Effects of CDP-Choline: A Dose-Dependent Study in the Toxic Cuprizone Model of De- and Remyelination
por: Gudi, Viktoria, et al.
Publicado: (2021)

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis
por: Konen, Franz Felix, et al.
Publicado: (2022)

Cognitive Performance of Patients with Adult 5q-Spinal Muscular Atrophy and with Amyotrophic Lateral Sclerosis
por: Osmanovic, Alma, et al.
Publicado: (2020)

The Future of Antisense Oligonucleotides in the Treatment of Respiratory Diseases
por: Ulanova, Marina, et al.
Publicado: (2012)

Cerebrospinal fluid analysis in 108 patients with progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2020)

Antisense oligonucleotides in neurological disorders
por: Wurster, Claudia D., et al.
Publicado: (2018)

Molecular Mechanisms of Antisense Oligonucleotides
por: Crooke, Stanley T.
Publicado: (2017)

Antisense oligonucleotides: A primer
por: Scoles, Daniel R., et al.
Publicado: (2019)

Antisense Oligonucleotides and RNA Interference
por: Kher, Gitanjali, et al.
Publicado: (2011)

Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis
por: Ratuszny, Dominica, et al.
Publicado: (2019)

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides
por: Reidenbach, Andrew G., et al.
Publicado: (2019)

Nusinersen Wearing-Off in Adult 5q-Spinal Muscular Atrophy Patients
por: Osmanovic, Alma, et al.
Publicado: (2021)

McDonald Criteria 2010 and 2005 Compared: Persistence of High Oligoclonal Band Prevalence Despite Almost Doubled Diagnostic Sensitivity
por: Schwenkenbecher, Philipp, et al.
Publicado: (2016)

Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis
por: Schwenkenbecher, Philipp, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0f78vo4u5ot72rtjfe1sh816kr