Cargando…

The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series

Best macular dystrophy (BMD) is an autosomal dominant macular dystrophy of childhood onset characterized by bilateral and symmetric vitelliform lesions. Several stages of disease have been well-described in the literature. Choroidal neovascularization (CNV) has traditionally been considered a hallma...

Descripción completa

Detalles Bibliográficos
Autores principales: Qaseem, Yaqoob, German, Olga, Cicinelli, Maria Vittoria, Mirza, Rukhsana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996930/
https://www.ncbi.nlm.nih.gov/pubmed/33673428
http://dx.doi.org/10.3390/medicina57030213
_version_ 1783670213087068160
author Qaseem, Yaqoob
German, Olga
Cicinelli, Maria Vittoria
Mirza, Rukhsana G.
author_facet Qaseem, Yaqoob
German, Olga
Cicinelli, Maria Vittoria
Mirza, Rukhsana G.
author_sort Qaseem, Yaqoob
collection PubMed
description Best macular dystrophy (BMD) is an autosomal dominant macular dystrophy of childhood onset characterized by bilateral and symmetric vitelliform lesions. Several stages of disease have been well-described in the literature. Choroidal neovascularization (CNV) has traditionally been considered a hallmark of end-stage disease, and anti-vascular endothelial growth factor (anti-VEGF) agents have been used to improve visual prognosis. While CNV was historically detected with fluorescein angiography, optical coherence tomography angiography (OCTA) has recently been employed as a novel mechanism for identifying CNV in BMD. In this case series, we discuss our institutional experience with using OCTA to detect CNV in BMD and contextualize this experience within the broader emerging literature. While OCTA allows for the identification of CNV in less severe stages of BMD, the management of this CNV remains uncertain.
format Online
Article
Text
id pubmed-7996930
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79969302021-03-27 The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series Qaseem, Yaqoob German, Olga Cicinelli, Maria Vittoria Mirza, Rukhsana G. Medicina (Kaunas) Case Report Best macular dystrophy (BMD) is an autosomal dominant macular dystrophy of childhood onset characterized by bilateral and symmetric vitelliform lesions. Several stages of disease have been well-described in the literature. Choroidal neovascularization (CNV) has traditionally been considered a hallmark of end-stage disease, and anti-vascular endothelial growth factor (anti-VEGF) agents have been used to improve visual prognosis. While CNV was historically detected with fluorescein angiography, optical coherence tomography angiography (OCTA) has recently been employed as a novel mechanism for identifying CNV in BMD. In this case series, we discuss our institutional experience with using OCTA to detect CNV in BMD and contextualize this experience within the broader emerging literature. While OCTA allows for the identification of CNV in less severe stages of BMD, the management of this CNV remains uncertain. MDPI 2021-02-27 /pmc/articles/PMC7996930/ /pubmed/33673428 http://dx.doi.org/10.3390/medicina57030213 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Case Report
Qaseem, Yaqoob
German, Olga
Cicinelli, Maria Vittoria
Mirza, Rukhsana G.
The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series
title The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series
title_full The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series
title_fullStr The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series
title_full_unstemmed The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series
title_short The Role of Optical Coherence Tomography Angiography (OCTA) in Detecting Choroidal Neovascularization in Different Stages of Best Macular Dystrophy: A Case Series
title_sort role of optical coherence tomography angiography (octa) in detecting choroidal neovascularization in different stages of best macular dystrophy: a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996930/
https://www.ncbi.nlm.nih.gov/pubmed/33673428
http://dx.doi.org/10.3390/medicina57030213
work_keys_str_mv AT qaseemyaqoob theroleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries
AT germanolga theroleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries
AT cicinellimariavittoria theroleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries
AT mirzarukhsanag theroleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries
AT qaseemyaqoob roleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries
AT germanolga roleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries
AT cicinellimariavittoria roleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries
AT mirzarukhsanag roleofopticalcoherencetomographyangiographyoctaindetectingchoroidalneovascularizationindifferentstagesofbestmaculardystrophyacaseseries