Cargando…
Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season
During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiven...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997015/ https://www.ncbi.nlm.nih.gov/pubmed/33770132 http://dx.doi.org/10.1371/journal.pone.0249005 |
_version_ | 1783670231619600384 |
---|---|
author | Shinjoh, Masayoshi Sugaya, Norio Yamaguchi, Yoshio Ookawara, Ichiro Nakata, Yuji Narabayashi, Atsushi Furuichi, Munehiro Yoshida, Naoko Kamei, Akinobu Kuramochi, Yuu Shibata, Akimichi Shimoyamada, Motoko Nakazaki, Hisataka Maejima, Naohiko Yuasa, Erika Araki, Eriko Maeda, Naonori Ohnishi, Takuma Nishida, Mitsuhiro Taguchi, Nobuhiko Yoshida, Makoto Tsunematsu, Kenichiro Shibata, Meiwa Hirano, Yasuhiro Sekiguchi, Shinichiro Kawakami, Chiharu Mitamura, Keiko Takahashi, Takao |
author_facet | Shinjoh, Masayoshi Sugaya, Norio Yamaguchi, Yoshio Ookawara, Ichiro Nakata, Yuji Narabayashi, Atsushi Furuichi, Munehiro Yoshida, Naoko Kamei, Akinobu Kuramochi, Yuu Shibata, Akimichi Shimoyamada, Motoko Nakazaki, Hisataka Maejima, Naohiko Yuasa, Erika Araki, Eriko Maeda, Naonori Ohnishi, Takuma Nishida, Mitsuhiro Taguchi, Nobuhiko Yoshida, Makoto Tsunematsu, Kenichiro Shibata, Meiwa Hirano, Yasuhiro Sekiguchi, Shinichiro Kawakami, Chiharu Mitamura, Keiko Takahashi, Takao |
author_sort | Shinjoh, Masayoshi |
collection | PubMed |
description | During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months–15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%–46%) and 74% (95% CI, 39%–89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%–77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. |
format | Online Article Text |
id | pubmed-7997015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-79970152021-04-06 Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season Shinjoh, Masayoshi Sugaya, Norio Yamaguchi, Yoshio Ookawara, Ichiro Nakata, Yuji Narabayashi, Atsushi Furuichi, Munehiro Yoshida, Naoko Kamei, Akinobu Kuramochi, Yuu Shibata, Akimichi Shimoyamada, Motoko Nakazaki, Hisataka Maejima, Naohiko Yuasa, Erika Araki, Eriko Maeda, Naonori Ohnishi, Takuma Nishida, Mitsuhiro Taguchi, Nobuhiko Yoshida, Makoto Tsunematsu, Kenichiro Shibata, Meiwa Hirano, Yasuhiro Sekiguchi, Shinichiro Kawakami, Chiharu Mitamura, Keiko Takahashi, Takao PLoS One Research Article During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h after the onset of illness. We assessed the vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children (6 months–15 years old, N = 4243), using a test-negative case-control design based on the results of RIDTs in the 2018/19 season. The VE against influenza A(H1N1)pdm and A(H3N2) was analyzed separately using an RIDT kit specifically for detecting A(H1N1)pdm09. The adjusted VE against combined influenza A (H1N1pdm and H3N2) and against A(H1N1)pdm09 was 39% (95% confidence interval [CI], 30%–46%) and 74% (95% CI, 39%–89%), respectively. By contrast, the VE against non-A(H1N1)pdm09 influenza A (presumed to be H3N2) was very low at 7%. The adjusted VE for preventing hospitalization was 56% (95% CI, 16%–77%) against influenza A. The VE against A(H1N1)pdm09 was consistently high in our studies. By contrast, the VE against A(H3N2) was low not only in adults but also in children in the 2018/19 season. Public Library of Science 2021-03-26 /pmc/articles/PMC7997015/ /pubmed/33770132 http://dx.doi.org/10.1371/journal.pone.0249005 Text en © 2021 Shinjoh et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shinjoh, Masayoshi Sugaya, Norio Yamaguchi, Yoshio Ookawara, Ichiro Nakata, Yuji Narabayashi, Atsushi Furuichi, Munehiro Yoshida, Naoko Kamei, Akinobu Kuramochi, Yuu Shibata, Akimichi Shimoyamada, Motoko Nakazaki, Hisataka Maejima, Naohiko Yuasa, Erika Araki, Eriko Maeda, Naonori Ohnishi, Takuma Nishida, Mitsuhiro Taguchi, Nobuhiko Yoshida, Makoto Tsunematsu, Kenichiro Shibata, Meiwa Hirano, Yasuhiro Sekiguchi, Shinichiro Kawakami, Chiharu Mitamura, Keiko Takahashi, Takao Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season |
title | Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season |
title_full | Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season |
title_fullStr | Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season |
title_full_unstemmed | Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season |
title_short | Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season |
title_sort | influenza vaccine effectiveness against influenza a in children based on the results of various rapid influenza tests in the 2018/19 season |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997015/ https://www.ncbi.nlm.nih.gov/pubmed/33770132 http://dx.doi.org/10.1371/journal.pone.0249005 |
work_keys_str_mv | AT shinjohmasayoshi influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT sugayanorio influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT yamaguchiyoshio influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT ookawaraichiro influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT nakatayuji influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT narabayashiatsushi influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT furuichimunehiro influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT yoshidanaoko influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT kameiakinobu influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT kuramochiyuu influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT shibataakimichi influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT shimoyamadamotoko influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT nakazakihisataka influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT maejimanaohiko influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT yuasaerika influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT arakieriko influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT maedanaonori influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT ohnishitakuma influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT nishidamitsuhiro influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT taguchinobuhiko influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT yoshidamakoto influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT tsunematsukenichiro influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT shibatameiwa influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT hiranoyasuhiro influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT sekiguchishinichiro influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT kawakamichiharu influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT mitamurakeiko influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season AT takahashitakao influenzavaccineeffectivenessagainstinfluenzaainchildrenbasedontheresultsofvariousrapidinfluenzatestsinthe201819season |