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Neuropilins: C-end rule peptides and their association with nociception and COVID-19
Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2). Considering the disparities in the transmission rate and viral tropism of the two coronaviruses, additional host factors wer...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Research Network of Computational and Structural Biotechnology
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997051/ https://www.ncbi.nlm.nih.gov/pubmed/33815686 http://dx.doi.org/10.1016/j.csbj.2021.03.025 |
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author | Jobe, Amie Vijayan, Ranjit |
author_facet | Jobe, Amie Vijayan, Ranjit |
author_sort | Jobe, Amie |
collection | PubMed |
description | Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2). Considering the disparities in the transmission rate and viral tropism of the two coronaviruses, additional host factors were suspected. Recently, a novel host factor for SARS-CoV-2 entry, neuropilin-1 (NRP-1) has been identified. These receptors potentiate viral infection in the presence of other host factors like ACE2. Through its C-end rule (CendR) motif exposed following furin processing, the SARS-CoV-2 spike protein binds to the CendR pocket of NRP-1 and achieves cell entry through endocytosis. The binding of SARS-CoV-2 spike protein to the NRP-1 receptor interferes with the docking of its endogenous ligand VEGF-A, signaling that would otherwise promote nociception. This review looks at the function of neuropilins and how it contributes to SARS-CoV-2 infection and nociception. |
format | Online Article Text |
id | pubmed-7997051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-79970512021-03-29 Neuropilins: C-end rule peptides and their association with nociception and COVID-19 Jobe, Amie Vijayan, Ranjit Comput Struct Biotechnol J Review Article Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2). Considering the disparities in the transmission rate and viral tropism of the two coronaviruses, additional host factors were suspected. Recently, a novel host factor for SARS-CoV-2 entry, neuropilin-1 (NRP-1) has been identified. These receptors potentiate viral infection in the presence of other host factors like ACE2. Through its C-end rule (CendR) motif exposed following furin processing, the SARS-CoV-2 spike protein binds to the CendR pocket of NRP-1 and achieves cell entry through endocytosis. The binding of SARS-CoV-2 spike protein to the NRP-1 receptor interferes with the docking of its endogenous ligand VEGF-A, signaling that would otherwise promote nociception. This review looks at the function of neuropilins and how it contributes to SARS-CoV-2 infection and nociception. Research Network of Computational and Structural Biotechnology 2021-03-26 /pmc/articles/PMC7997051/ /pubmed/33815686 http://dx.doi.org/10.1016/j.csbj.2021.03.025 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Jobe, Amie Vijayan, Ranjit Neuropilins: C-end rule peptides and their association with nociception and COVID-19 |
title | Neuropilins: C-end rule peptides and their association with nociception and COVID-19 |
title_full | Neuropilins: C-end rule peptides and their association with nociception and COVID-19 |
title_fullStr | Neuropilins: C-end rule peptides and their association with nociception and COVID-19 |
title_full_unstemmed | Neuropilins: C-end rule peptides and their association with nociception and COVID-19 |
title_short | Neuropilins: C-end rule peptides and their association with nociception and COVID-19 |
title_sort | neuropilins: c-end rule peptides and their association with nociception and covid-19 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997051/ https://www.ncbi.nlm.nih.gov/pubmed/33815686 http://dx.doi.org/10.1016/j.csbj.2021.03.025 |
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