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Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve?
Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the dete...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997102/ https://www.ncbi.nlm.nih.gov/pubmed/33786373 http://dx.doi.org/10.1097/TXD.0000000000001142 |
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author | Onsøien, Mari O. Midtvedt, Karsten Reisæter, Anna V. Aasarød, Knut Waldum-Grevbo, Bård Vikse, Bjørn Egil Eriksen, Bjørn Odvar Åsberg, Anders |
author_facet | Onsøien, Mari O. Midtvedt, Karsten Reisæter, Anna V. Aasarød, Knut Waldum-Grevbo, Bård Vikse, Bjørn Egil Eriksen, Bjørn Odvar Åsberg, Anders |
author_sort | Onsøien, Mari O. |
collection | PubMed |
description | Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the determinants of failure to achieve BP control. METHODS. In conjunction with the 2018 annual data reporting, additional questions were added for recipients with BP >130/80 mm Hg (treating physician´s target BP for each patient, reasons for not achieving target, method of measurement). RESULTS. Annual forms were received from 98% (3407 of 3486) of KTx recipients, with 1787 (52%) reporting a BP >130/80 mm Hg (“above-target” group). These recipients were older, mostly male, with higher body mass index and serum creatinine levels (P < 0.05) compared with patients with controlled hypertension (“on-target” group). Valid survey answers were available for 84% of the “above-target” group (Surv(resp)) with no significant demographic differences versus nonresponders (Surv(nonresp)). Among Surv(resp), 32% were under antihypertensive dose titration, whereas dose-limiting side effects were reported in 7%. Target BP was confirmed to 130/80 mm Hg for 60% of Surv(resp). In recipients for whom the treating physician set target BP >130/80 mm Hg, 51% did not reach these individual targets. The number of antihypertensive drugs was significantly higher in the “above-target” group versus “on-target” group (mean 2.1 ± 1.2 versus 1.8 ± 1.3) and 36% versus 25% used ≥3 antihypertensive drugs (P < 0.05). Automatic attended BP measurement was utilized by 51%. CONCLUSIONS. In KTx recipients, a higher BP target achievement seems possible, potentially in the range of 75%-80%. |
format | Online Article Text |
id | pubmed-7997102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-79971022021-03-29 Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? Onsøien, Mari O. Midtvedt, Karsten Reisæter, Anna V. Aasarød, Knut Waldum-Grevbo, Bård Vikse, Bjørn Egil Eriksen, Bjørn Odvar Åsberg, Anders Transplant Direct Kidney Transplantation Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the determinants of failure to achieve BP control. METHODS. In conjunction with the 2018 annual data reporting, additional questions were added for recipients with BP >130/80 mm Hg (treating physician´s target BP for each patient, reasons for not achieving target, method of measurement). RESULTS. Annual forms were received from 98% (3407 of 3486) of KTx recipients, with 1787 (52%) reporting a BP >130/80 mm Hg (“above-target” group). These recipients were older, mostly male, with higher body mass index and serum creatinine levels (P < 0.05) compared with patients with controlled hypertension (“on-target” group). Valid survey answers were available for 84% of the “above-target” group (Surv(resp)) with no significant demographic differences versus nonresponders (Surv(nonresp)). Among Surv(resp), 32% were under antihypertensive dose titration, whereas dose-limiting side effects were reported in 7%. Target BP was confirmed to 130/80 mm Hg for 60% of Surv(resp). In recipients for whom the treating physician set target BP >130/80 mm Hg, 51% did not reach these individual targets. The number of antihypertensive drugs was significantly higher in the “above-target” group versus “on-target” group (mean 2.1 ± 1.2 versus 1.8 ± 1.3) and 36% versus 25% used ≥3 antihypertensive drugs (P < 0.05). Automatic attended BP measurement was utilized by 51%. CONCLUSIONS. In KTx recipients, a higher BP target achievement seems possible, potentially in the range of 75%-80%. Lippincott Williams & Wilkins 2021-03-25 /pmc/articles/PMC7997102/ /pubmed/33786373 http://dx.doi.org/10.1097/TXD.0000000000001142 Text en Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Kidney Transplantation Onsøien, Mari O. Midtvedt, Karsten Reisæter, Anna V. Aasarød, Knut Waldum-Grevbo, Bård Vikse, Bjørn Egil Eriksen, Bjørn Odvar Åsberg, Anders Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title | Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_full | Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_fullStr | Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_full_unstemmed | Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_short | Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_sort | blood pressure treatment in kidney transplant recipients—can we improve? |
topic | Kidney Transplantation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997102/ https://www.ncbi.nlm.nih.gov/pubmed/33786373 http://dx.doi.org/10.1097/TXD.0000000000001142 |
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