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Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

[Image: see text] Alzheimer’s disease is associated with the deposition of the amyloid-β peptide (Aβ) into extracellular senile plaques in the brain. In vitro and in vivo observations have indicated that transthyretin (TTR) acts as an Aβ scavenger in the brain, but the mechanism has not been fully r...

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Detalles Bibliográficos
Autores principales:	Ghadami, Seyyed Abolghasem, Chia, Sean, Ruggeri, Francesco Simone, Meisl, Georg, Bemporad, Francesco, Habchi, Johnny, Cascella, Roberta, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J., Chiti, Fabrizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997117/ https://www.ncbi.nlm.nih.gov/pubmed/32011129 http://dx.doi.org/10.1021/acs.biomac.9b01475

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