Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance

In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combinati...

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Autores principales: Ko, Jae-Hoon, Joo, Eun-Jeong, Baek, Jin Yang, Huh, Kyungmin, Cho, Sun Young, Kang, Cheol-In, Chung, Doo Ryeon, Kim, Yae-Jean, Kang, Eun-Suk, Peck, Kyong Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997140/
https://www.ncbi.nlm.nih.gov/pubmed/33836943
http://dx.doi.org/10.1016/j.jmii.2021.03.008
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author Ko, Jae-Hoon
Joo, Eun-Jeong
Baek, Jin Yang
Huh, Kyungmin
Cho, Sun Young
Kang, Cheol-In
Chung, Doo Ryeon
Kim, Yae-Jean
Kang, Eun-Suk
Peck, Kyong Ran
author_facet Ko, Jae-Hoon
Joo, Eun-Jeong
Baek, Jin Yang
Huh, Kyungmin
Cho, Sun Young
Kang, Cheol-In
Chung, Doo Ryeon
Kim, Yae-Jean
Kang, Eun-Suk
Peck, Kyong Ran
author_sort Ko, Jae-Hoon
collection PubMed
description In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased.
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spelling pubmed-79971402021-03-29 Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance Ko, Jae-Hoon Joo, Eun-Jeong Baek, Jin Yang Huh, Kyungmin Cho, Sun Young Kang, Cheol-In Chung, Doo Ryeon Kim, Yae-Jean Kang, Eun-Suk Peck, Kyong Ran J Microbiol Immunol Infect Short Communication In an investigation of six anti-SARS-CoV-2 antibody kits with different target antigen and methodology, each kit showed comparable performance. As false-positive reactions occurred independently with different kits, specificity increased to 100% when pairs of kits were used. With three-kit combination, both sensitivity (99.1%) and specificity (100%) increased. Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. 2021-10 2021-03-26 /pmc/articles/PMC7997140/ /pubmed/33836943 http://dx.doi.org/10.1016/j.jmii.2021.03.008 Text en © 2021 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Ko, Jae-Hoon
Joo, Eun-Jeong
Baek, Jin Yang
Huh, Kyungmin
Cho, Sun Young
Kang, Cheol-In
Chung, Doo Ryeon
Kim, Yae-Jean
Kang, Eun-Suk
Peck, Kyong Ran
Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance
title Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance
title_full Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance
title_fullStr Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance
title_full_unstemmed Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance
title_short Evaluation of six anti-SARS-CoV-2 antibody test kits and practical approaches to optimize the diagnostic performance
title_sort evaluation of six anti-sars-cov-2 antibody test kits and practical approaches to optimize the diagnostic performance
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997140/
https://www.ncbi.nlm.nih.gov/pubmed/33836943
http://dx.doi.org/10.1016/j.jmii.2021.03.008
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