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Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study

Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing Enterobacteriaceae (ESBL-E), such as Escherichia coli, hamper the treatment of infections, resulting in high morbidity. E. coli is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infant...

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Autores principales: Frank Wolf, Maya, Abu Shqara, Raneen, Naskovica, Karina, Zilberfarb, Inna Amdur, Sgayer, Inshirah, Glikman, Daniel, Rechnitzer, Hagai, Fleisher Sheffer, Vered, Bornstein, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997221/
https://www.ncbi.nlm.nih.gov/pubmed/33673648
http://dx.doi.org/10.3390/microorganisms9030506
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author Frank Wolf, Maya
Abu Shqara, Raneen
Naskovica, Karina
Zilberfarb, Inna Amdur
Sgayer, Inshirah
Glikman, Daniel
Rechnitzer, Hagai
Fleisher Sheffer, Vered
Bornstein, Jacob
author_facet Frank Wolf, Maya
Abu Shqara, Raneen
Naskovica, Karina
Zilberfarb, Inna Amdur
Sgayer, Inshirah
Glikman, Daniel
Rechnitzer, Hagai
Fleisher Sheffer, Vered
Bornstein, Jacob
author_sort Frank Wolf, Maya
collection PubMed
description Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing Enterobacteriaceae (ESBL-E), such as Escherichia coli, hamper the treatment of infections, resulting in high morbidity. E. coli is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (p = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS.
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spelling pubmed-79972212021-03-27 Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study Frank Wolf, Maya Abu Shqara, Raneen Naskovica, Karina Zilberfarb, Inna Amdur Sgayer, Inshirah Glikman, Daniel Rechnitzer, Hagai Fleisher Sheffer, Vered Bornstein, Jacob Microorganisms Article Maternal carriage and vertical transmission of extended-spectrum, beta-lactamase-producing Enterobacteriaceae (ESBL-E), such as Escherichia coli, hamper the treatment of infections, resulting in high morbidity. E. coli is the most frequent cause of early-onset neonatal sepsis (EOS) in preterm infants, where ESBL-E are more frequently isolated. In this prospective, case-controlled study, maternal rectovaginal ESBL-E colonization and vertical transmission to preterm infants were assessed in 160 women with preterm premature rupture of membranes (PPROM; 57.4%) or preterm labor (42.6%); additional cultures were obtained from the placenta, amnion, and umbilical cord during preterm labor. Maternal and neonatal ESBL-E-carriage rates were 17.5% and 12.9%, respectively, and the vertical-transmission rate was 50%. Maternal ESBL-E colonization among women with PPROM was 21.3%, and in women with premature labor it was 12.6%. No correlation was observed between maternal ESBL-E-colonization and previous hospitalization or antibiotic administration during pregnancy. However, a correlation was found between placental inflammation and maternal ESBL-E colonization (p = 0.007). ESBL-E-colonized infants were delivered at an earlier gestational age and were more likely to have complications. Thus, the high ESBL-E carriage rate in women with threatened preterm labor, without obvious risk factors for carriage, and a high vertical transmission rate, combined with a correlation between placental inflammation and ESBL-E carriage, support maternal–neonatal ESBL-E-colonization surveillance and active measures to prevent ESBL-E-related EOS. MDPI 2021-02-27 /pmc/articles/PMC7997221/ /pubmed/33673648 http://dx.doi.org/10.3390/microorganisms9030506 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Frank Wolf, Maya
Abu Shqara, Raneen
Naskovica, Karina
Zilberfarb, Inna Amdur
Sgayer, Inshirah
Glikman, Daniel
Rechnitzer, Hagai
Fleisher Sheffer, Vered
Bornstein, Jacob
Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study
title Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study
title_full Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study
title_fullStr Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study
title_full_unstemmed Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study
title_short Vertical Transmission of Extended-Spectrum, Beta-Lactamase-Producing Enterobacteriaceae during Preterm Delivery: A Prospective Study
title_sort vertical transmission of extended-spectrum, beta-lactamase-producing enterobacteriaceae during preterm delivery: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997221/
https://www.ncbi.nlm.nih.gov/pubmed/33673648
http://dx.doi.org/10.3390/microorganisms9030506
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